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Abstract

Objectives: Health state utilities (HSUs) are an input metric for estimating quality-adjusted life-years (QALY) in cost-utility analyses. Currently, there is a paucity of data on association of knee symptoms with HSUs for middle-aged populations. We aimed to describe the association of knee symptoms and change in knee symptoms with SF-6D HSUs and described the distribution of HSUs against knee symptoms' severity.Methods: Participants (36-49-years) were selected from the third follow-up (completed 2019) of Australian Childhood Determinants of Adult Health study. SF-6D HSUs were generated from the participant-reported SF-12. Association between participant-reported WOMAC knee symptoms' severity, change in knee symptoms over 6-9 years, and HSUs were evaluated using linear regression models.Results: For the cross-sectional analysis, 1,567 participants were included; mean age 43.5 years, female 54%, BMI ± SD 27.18 ± 5.31 kg/m2. Mean ± SD HSUs for normal, moderate, and severe WOMAC scores were 0.820 ± 0.120, 0.800 ± 0.120, and 0.740 ± 0.130, respectively. A significant association was observed between worsening knee symptoms and HSUs in univariable and multivariable analyses after adjustment (age and sex). HSU decrement for normal-to-severe total-WOMAC and WOMAC-pain was - 0.080 (95% CI - 0.100 to - 0.060, p p Conclusion: In a middle-aged population-based sample, there was an independent negative association between worse knee symptoms and SF-6D HSUs. Our findings may be used by decision-makers to define more realistic and conservative baseline and ongoing HSU values when assessing QALY changes associated with osteoarthritis interventions.

Item Type:	Article
Authors/Creators:	Singh, A and Campbell, JA and Venn, A and Jones, G and Blizzard, L and Palmer, AJ and Dwyer, T and Cicuttini, F and Ding, C and Antony, B
Keywords:	health state utility, osteoarthritis, population norm, QALY, SF-6D, WOMAC
Journal or Publication Title:	Quality of Life Research
Publisher:	Kluwer Academic Publ
ISSN:	0962-9343
DOI / ID Number:	10.1007/s11136-021-02859-5
Copyright Information:	Copyright 2021 The Authors, under exclusive licence to Springer Nature Switzerland AG
Related URLs:	Google Scholar: Venn, A UTAS Profile: Venn, A Google Scholar: Jones, G UTAS Profile: Jones, G UTAS Profile: Blizzard, L UTAS Profile: Palmer, AJ Google Scholar: Ding, C UTAS Profile: Ding, C Google Scholar: Antony, B
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