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AMPK signaling in energy control, cartilage biology, and osteoarthritis

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Yi, D, Yu, H, Lu, K, Ruan, C, Ding, C ORCID: 0000-0002-9479-730X, Tong, L, Zhao, X and Chen, D 2021 , 'AMPK signaling in energy control, cartilage biology, and osteoarthritis' , Frontiers in Cell and Developmental Biology, vol. 9 , pp. 1-14 , doi: 10.3389/fcell.2021.696602.

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Abstract

The adenosine monophosphate (AMP)-activated protein kinase (AMPK) was initially identified as an enzyme acting as an "energy sensor" in maintaining energy homeostasis via serine/threonine phosphorylation when low cellular adenosine triphosphate (ATP) level was sensed. AMPK participates in catabolic and anabolic processes at the molecular and cellular levels and is involved in appetite-regulating circuit in the hypothalamus. AMPK signaling also modulates energy metabolism in organs such as adipose tissue, brain, muscle, and heart, which are highly dependent on energy consumption via adjusting the AMP/ADP:ATP ratio. In clinics, biguanides and thiazolidinediones are prescribed to patients with metabolic disorders through activating AMPK signaling and inhibiting complex I in the mitochondria, leading to a reduction in mitochondrial respiration and elevated ATP production. The role of AMPK in mediating skeletal development and related diseases remains obscure. In this review, in addition to discuss the emerging advances of AMPK studies in energy control, we will also illustrate current discoveries of AMPK in chondrocyte homeostasis, osteoarthritis (OA) development, and the signaling interaction of AMPK with other pathways, such as mTOR (mechanistic target of rapamycin), Wnt, and NF-κB (nuclear factor κB) under OA condition.

Item Type: Article
Authors/Creators:Yi, D and Yu, H and Lu, K and Ruan, C and Ding, C and Tong, L and Zhao, X and Chen, D
Keywords: AMPK, chondrocyte, energy balance, osteoarthritis, signaling interaction
Journal or Publication Title: Frontiers in Cell and Developmental Biology
Publisher: Frontiers Media S.A.
ISSN: 2296-634X
DOI / ID Number: 10.3389/fcell.2021.696602
Copyright Information:

Copyright 2021 Yi, Yu, Lu, Ruan, Ding, Tong, Zhao and Chen. This is an openaccess article distributed under the terms of the Creative Commons AttributionLicense (CC BY). The use, distribution or reproduction in other forums is permitted,provided the original author(s) and the copyright owner(s) are credited and that theoriginal publication in this journal is cited, in accordance with accepted academicpractice. No use, distribution or reproduction is permitted which does not complywith these terms.

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