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Abstract

Importance and objectives: There is unmet medical need to understand the pathogenic mechanism of the panoplyof clinical manifestations associated with silicone breast implants (SBIs) such as severe fatigue, widespread pain,palpitations, dry mouth and eyes, depression, hearing loss etc. We aimed to determine whether autoantibodiesagainst the autonomic nervous system receptors can explain the enigmatic and subjective clinical manifestationreported by women with SBIs.Results: Circulating level of autoantibodies against G protein-coupled receptors (GPCRs) of the autonomic nervous system (adrenergic, muscarinic, endothelin and angiotensin receptors) have been evaluated in symptomaticwomen with SBIs using an ELISA method. These women with SBIs addressed our clinic due to various subjectiveand autonomic-related manifestations such as chronic severe fatigue, cognitive impairment, widespread pain,memory loss, sleep disorders, palpitations, depression, hearing abnormalities etc. We report for the first time, asignificant reduction in the sera level of anti-β1 adrenergic receptor (p Conclusions: Chronic immune stimulation by silicone material may lead to an autoimmune dysautonomia in asubgroup of potentially genetically susceptible women with SBIs. The appearance of autoantibodies againstGPCRs of the autonomic nervous system serve as an explanation for the subjective autonomic-related manifestations reported in women with SBIs.

Item Type:	Article
Authors/Creators:	Halpert, G and Watad, A and Tsur, AM and Dotan, A and Quiros-Lim, HE and Heidecke, H and Gilburd, B and Haik, J and Levy, Y and Blank, M and Amital, H and Shoenfeld, Y
Keywords:	autoantibodies, dysautonomia, G-protein coupled-receptors, autonomic nervous system, adrenergic receptor, silicone breast implants
Journal or Publication Title:	Journal of Autoimmunity
Publisher:	Elsevier BV
ISSN:	0896-8411
DOI / ID Number:	10.1016/j.jaut.2021.102631
Copyright Information:	© 2021 Elsevier Ltd. All rights reserved.
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