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Cardiovascular disease predicts structural and functional progression in early glaucoma

Marshall, H, Mullany, S, Qassim, A, Siggs, O, Hassall, M, Ridge, B, Nguyen, T, Awadalla, M, Andrew, NH, Healey, PR, Agar, A, Galanopoulos, A, Hewitt, AW ORCID: 0000-0002-5123-5999, MacGregor, S, Graham, SL, Mills, R, Shulz, A, Landers, J, Casson, RJ and Craig, JE 2021 , 'Cardiovascular disease predicts structural and functional progression in early glaucoma' , Ophthalmology, vol. 128, no. 1 , pp. 58-69 , doi: 10.1016/j.ophtha.2020.06.067.

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Purpose:To investigate the association between cardiovascular disease and baseline structural defects and disease progression in glaucoma.Design: Prospective, longitudinal study of preperimetric and perimetric glaucoma.Participants: Two thousand six hundred twenty-eight eyes from 1314 participants recruited to the Progression Risk of Glaucoma: Relevant SNPs with Significant Association (PROGRESSA) study were evaluated for baseline and longitudinal structural thinning using spectral-domain OCT and for visual field progression on Humphrey visual field (HVF) assessment.Methods: Patients were classified as either predominantly macula ganglion cell-inner plexiform layer (mGCIPL), predominantly peripapillary retinal nerve fiber layer (pRNFL), or both mGCIPL and pRNFL structural change at enrollment, and then evaluated for longitudinal OCT or HVF progression. Cardiovascular disease and medication characteristics of the participants were compared with a reference group of stable patients.Main outcome measures: OCT and HVF baseline status and longitudinal progression.Results: After accounting for age and cardiovascular characteristics, patients with predominantly mGCIPL thinning at baseline showed a higher prevalence of hypertension (odds ratio [OR], 2.70; 95% confidence interval [CI], 1.66-4.41; P

Item Type: Article
Authors/Creators:Marshall, H and Mullany, S and Qassim, A and Siggs, O and Hassall, M and Ridge, B and Nguyen, T and Awadalla, M and Andrew, NH and Healey, PR and Agar, A and Galanopoulos, A and Hewitt, AW and MacGregor, S and Graham, SL and Mills, R and Shulz, A and Landers, J and Casson, RJ and Craig, JE
Keywords: OCT, cardiovascular disease, glaucoma
Journal or Publication Title: Ophthalmology
Publisher: Elsevier
ISSN: 0161-6420
DOI / ID Number: 10.1016/j.ophtha.2020.06.067
Copyright Information:

Copyright 2020 Crown Copyright. Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology

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