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Influence of tDCS over right inferior frontal gyrus and pre-supplementary motor area on perceptual decision-making and response inhibition: A healthy ageing perspective

Fujiyama, H, Tan, J, Puri, R ORCID: 0000-0002-0231-1369 and Hinder, MR ORCID: 0000-0002-5240-4790 2022 , 'Influence of tDCS over right inferior frontal gyrus and pre-supplementary motor area on perceptual decision-making and response inhibition: A healthy ageing perspective' , Neurobiology of Aging, vol. 109 , pp. 11-21 , doi: 10.1016/j.neurobiolaging.2021.09.014.

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Abstract

A wide body of literature suggests that transcranial direct current stimulation (tDCS) administered overthe prefrontal cortex can improve executive function – including decision-making and inhibitory control– in healthy young adults. However, the effects of tDCS in older adults are largely unknown. Here, using a double-blind, sham-controlled approach, changes in a combined perceptual decision-making andinhibitory control task were assessed before and after the application of tDCS (1 mA, 20 minute) targeting the right inferior frontal gyrus (rIFG) or pre-supplementary motor area (preSMA) in 42 young (18–34years) and 41 older (60–80 years) healthy adults. Compared to sham stimulation, anodal tDCS over thepreSMA improved decision-making speed for both age groups. Furthermore, the inhibitory control performance of older and younger adults was improved by preSMA and rIFG stimulation, respectively. Thisstudy provides evidence that tDCS can improve both perceptual decision-making and inhibitory control inhealthy older adults, with the causal role of the preSMA and rIFG regions in cognitive control appearingto vary as a function of healthy ageing.

Item Type: Article
Authors/Creators:Fujiyama, H and Tan, J and Puri, R and Hinder, MR
Keywords: inhibitory control, ageing, cognitive control
Journal or Publication Title: Neurobiology of Aging
Publisher: Elsevier Science Inc
ISSN: 0197-4580
DOI / ID Number: 10.1016/j.neurobiolaging.2021.09.014
Copyright Information:

© 2021 Elsevier Inc.

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