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Effects of a physical activity intervention on brain atrophy in older adults at risk of dementia: a randomized controlled trial

Sinclair, B, Steward, C, Venkatraman, V, Aljondi, R, Cox, KL, Ellis, KA, Ames, D, Masters, CL, Phal, PM, Sharman, MJ ORCID: 0000-0003-1005-4793, Cyarto, EV, Lai, MMY, Szoeke, C, Lautenschlager, NT and Desmond, PM 2021 , 'Effects of a physical activity intervention on brain atrophy in older adults at risk of dementia: a randomized controlled trial' , Brain Imaging and Behavior , doi: 10.1007/s11682-021-00577-7.

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Abstract

Lack of physical activity is a risk factor for dementia, however, the utility of interventional physical activity programs as a protective measure against brain atrophy and cognitive decline is uncertain. Here we present the effect of a randomized controlled trial of a 24-month physical activity intervention on global and regional brain atrophy as characterized by longitudinal voxel-based morphometry with T1-weighted MRI images. The study sample consisted of 98 participants at risk of dementia, with mild cognitive impairment or subjective memory complaints, and having at least one vascular risk factor for dementia, randomized into an exercise group and a control group. Between 0 and 24 months, there was no significant difference detected between groups in the rate of change in global, or regional brain volumes.

Item Type: Article
Authors/Creators:Sinclair, B and Steward, C and Venkatraman, V and Aljondi, R and Cox, KL and Ellis, KA and Ames, D and Masters, CL and Phal, PM and Sharman, MJ and Cyarto, EV and Lai, MMY and Szoeke, C and Lautenschlager, NT and Desmond, PM
Keywords: dementia, mild cognitive impairment, physical activity, brain volume, voxel-based morphometry
Journal or Publication Title: Brain Imaging and Behavior
Publisher: Springer
ISSN: 1931-7557
DOI / ID Number: 10.1007/s11682-021-00577-7
Copyright Information:

© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021

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