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Reliability of updated left ventricular diastolic function recommendations in predicting elevated left ventricular filling pressure and prognosis

Sato, K, Grant, ADM, Negishi, K ORCID: 0000-0002-9086-2565, Cremer, PC, Negishi, T, Kumar, A, Collier, P, Kapadia, SR, Grimm, RA, Desai, MY, Griffin, BP and Popovic, ZB 2017 , 'Reliability of updated left ventricular diastolic function recommendations in predicting elevated left ventricular filling pressure and prognosis' , American Heart Journal, vol. 189 , pp. 28-39 , doi: 10.1016/j.ahj.2017.03.022.

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Background: An updated 2016 echocardiographic algorithm for diagnosing left ventricular (LV) diastolic dysfunction (DD) was recently proposed. We aimed to assess the reliability of the 2016 echocardiographic LVDD grading algorithm in predicting elevated LV filling pressure and clinical outcomes compared to the 2009 version.Methods: We retrospectively identified 460 consecutive patients without atrial fibrillation or significant mitral valve disease who underwent transthoracic echocardiography within 24 hours of elective heart catheterization. LV end-diastolic pressure (LVEDP) and the time constant of isovolumic pressure decay (Tau) were determined. The association between DD grading by 2009 LVDD Recommendations and 2016 Recommendations with hemodynamic parameters and all-cause mortality were compared.Results: The 2009 LVDD Recommendations classified 55 patients (12%) as having normal, 132 (29%) as grade 1, 156 (34%) as grade 2, and 117 (25%) as grade 3 DD. Based on 2016 Recommendations, 177 patients (38%) were normal, 50 (11%) were indeterminate, 124 (27%) patients were grade 1, 75 (16%) were grade 2, 26 (6%) were grade 3 DD, and 8 (2%) were cannot determine. The 2016 Recommendations had superior discriminatory accuracy in predicting LVEDP (P P = 0.039, subdistribution HR1.85 [95% CI, 1.03-3.33]) in multivariable competing risk regression.Conclusions: The grading algorithm proposed by the 2016 LV diastolic dysfunction Recommendations detects elevated LVEDP and poor prognosis better than the 2009 Recommendations.

Item Type: Article
Authors/Creators:Sato, K and Grant, ADM and Negishi, K and Cremer, PC and Negishi, T and Kumar, A and Collier, P and Kapadia, SR and Grimm, RA and Desai, MY and Griffin, BP and Popovic, ZB
Journal or Publication Title: American Heart Journal
Publisher: Mosby
ISSN: 0002-8703
DOI / ID Number: 10.1016/j.ahj.2017.03.022
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Copyright 2017 Elsevier Inc.

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