Open Access Repository

Altering systemic acid-base balance through nutrition failed to change secondary sex ratio


Downloads per month over past year

Roche, JR and Lee, JM 2007 , 'Altering systemic acid-base balance through nutrition failed to change secondary sex ratio' , Reproduction, Fertility and Development, vol. 19, no. 8 , pp. 887-890 , doi: 10.1071/RD06053.

[img] PDF
3904.pdf | Request a copy
Full text restricted
Available under University of Tasmania Standard License.


There is evidence that differences in either maternal blood pH or dietary mineral content can result in alterations
in secondary sex ratio in mammals. Altering the proportions of certain dietary minerals is known to influence blood pH,
offering a possible explanation for this effect of diet on secondary sex ratio. The present study was performed to investigate
whether altering blood pH by manipulating the dietary cation–anion difference (DCAD) would alter secondary sex ratio.
The DCAD is calculated (in mEq per 100 g dry matter) as the difference between metabolically strong cations (Na+K)
and metabolically strong anions (Cl+S) in the diet. Three hundred female mice were randomly allocated to either a low
or high DCAD ration for 3 weeks before coitus. Urine pH was monitored before beginning the experiment, as well as
before and after the breeding period, as a proxy for blood pH. Mice on the low DCAD diet had a lower urine pH (mean
(±s.d.) 6.0±0.1) than mice on the high DCAD diet (8.2±0.6), but DCAD did not affect the percentage of mice that
became pregnant, the number of offspring per pregnant mouse or the sex ratio of the neonate group. These results suggest
that blood pH alone does not alter sex ratio and that an altered systemic pH is not the reason for reported mineral-related
variations in sex ratio.

Item Type: Article
Authors/Creators:Roche, JR and Lee, JM
Keywords: blood pH, dietary cation–anion difference, minerals, urine pH.
Journal or Publication Title: Reproduction, Fertility and Development
Publisher: CSIRO
ISSN: 1031-3613
DOI / ID Number: 10.1071/RD06053
Additional Information:

© CSIRO 2007

Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page