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Attenuation of acute systemic inflammatory response after valve surgery


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Hadi, NR, Al-Amran, FG, Naeem, AA, Abd alsaheb, AF, Alturfy, MA, Fakher, WK, Majeed, YQ, Alharis, NR and Al-Aubaidy, HA ORCID: 0000-0001-9564-0120 2017 , 'Attenuation of acute systemic inflammatory response after valve surgery' , Journal of Contemporary Medical Sciences, vol. 3, no. 11 , 273–277 .

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Objective: This study highlights the protective effects of montelukast on myocardial ischemic reperfusion injury induced by cardiopulmonarybypass during valve replacement surgery.Methods: A total of 60 patients with valvular disease undergoing elective valve surgery were enrolled in this randomized single-blinded study.Participants were divided into two main groups: Montelukast-treated group consisted of 30 patients who were given 10 mg montelukast sodium(Singulair®, MSD, USA) tablet, once daily at bedtime for 3 days before valve surgery. Control group consisted of 30 patients who underwent valvesurgery without taking montelukast tablets. Blood samples were collected at following times (T0; T1 before aortic cross clamp; T2 after aortic crossclamp; and T3 24 h after the surgery), for measuring several inflammatory markers. Ejection fraction (EF) was measured before surgery and threemonths after surgery. Pulmonary functions were measured before and after the surgery in both study groups.Results: There were significant increase in the levels of TNF-a, IL-6, a2 macroglobulin/creatinine ratio and CTnI, in the control groupcompared to the montelukast-treated group among different study times, (P Conclusion: This study shows the benefits of using pre-surgical montelukast supplement in ameliorating the inflammatory process inpatients undergoing cardiopulmonary bypass during valve replacement surgery.

Item Type: Article
Authors/Creators:Hadi, NR and Al-Amran, FG and Naeem, AA and Abd alsaheb, AF and Alturfy, MA and Fakher, WK and Majeed, YQ and Alharis, NR and Al-Aubaidy, HA
Keywords: montelukast; mitral and aortic valve replacement surgery; ischemia reperfusion injury; interleukin-6; cardiac troponin 1; tumor necrotic factor-alpha.
Journal or Publication Title: Journal of Contemporary Medical Sciences
Publisher: Avicenna Publishing Corporation
ISSN: 2413-0516
Copyright Information:

Copyright 2017 The AuthorsLicensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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