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Ambulatory activity interacts with common risk factors for osteoarthritis to modify increases in MRI-detected osteophytes

Zhu, Z, Aitken, D ORCID: 0000-0001-5685-7634, Cicuttini, F, Jones, G ORCID: 0000-0002-9814-0006 and Ding, C ORCID: 0000-0002-9479-730X 2019 , 'Ambulatory activity interacts with common risk factors for osteoarthritis to modify increases in MRI-detected osteophytes' , Osteoarthritis and Cartilage, vol. 27, no. 4 , pp. 650-658 , doi: 10.1016/j.joca.2018.12.023.

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Objective: To investigate the longitudinal association between objectively measured ambulatory activity (AA) and knee MRI-detected osteophytes (OPs), and to test whether this relationship was modified by common risk factors for OA including sex, obesity, disease severity and knee injury history.Methods: 408 community-dwelling adults aged 51-81 years were assessed at baseline and 2.7 years. T1-weighted fat-suppressed MRI was used to evaluate knee OPs at both time points. AA was assessed at baseline by pedometers and categorized as: less active (≤7499 steps per day), moderately active (7500-9999 steps per day) and highly active (≥10,000 steps per day).Results: Statistically significant interactions were detected between knee OA risk factors and AA on increases in MRI-detected OPs (all P P P P = 0.02) and those with a history of knee injury (RR = 0.27, 95%CI, 0.08-0.88, P = 0.02) in almost every knee compartment, after adjustment for confounders. No statistically significant associations were found in males, non-obese, non-ROA or non-injury groups.Conclusions: Being moderately active is protective against an increase in MRI-detected OPs in females, those with ROA, those who are obese and those with a history of knee injury. These findings suggest that being moderately active is beneficial for individuals who are at higher risk of knee OA.

Item Type: Article
Authors/Creators:Zhu, Z and Aitken, D and Cicuttini, F and Jones, G and Ding, C
Keywords: ambulatory activity, magnetic resonance imaging, osteoarthritis, osteophytes, risk factors
Journal or Publication Title: Osteoarthritis and Cartilage
Publisher: W B Saunders Co Ltd
ISSN: 1063-4584
DOI / ID Number: 10.1016/j.joca.2018.12.023
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Copyright 2019 Osteoarthritis Research Society International

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