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Transfusion rates with intravenous tranexamic acid in total hip arthroplasty performed using the direct anterior approach


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Free, MD, Owen, DH, Pascoe, E, Allen, P ORCID: 0000-0003-1945-8049, Yang, L and Harvie, P 2019 , 'Transfusion rates with intravenous tranexamic acid in total hip arthroplasty performed using the direct anterior approach' , HIP International, vol. 29, no. 5 , pp. 511-515 , doi: 10.1177/1120700018811310.

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Introduction: Tranexamic acid (TXA) has been shown to reduce blood loss and transfusion requirements in patientsundergoing total hip arthroplasty (THA). Most studies have focused on TXA in THA performed using a posteriorapproach (PA) or lateral approach. The aim of this study was to analyse the efficacy of TXA in patients undergoing THAusing the direct anterior approach (DAA).Patients and methods: Using our institutional database, a retrospective analysis was conducted on consecutiveprimary THA performed for osteoarthritis to determine transfusion rates in patients undergoing THA with the DAAwith and without TXA.Results: 146 consecutive THA were performed using DAA: 83 (56.8%) patients had TXA and 63 (43.2%) did not haveTXA. Among patients who had TXA, 1 patient required a blood transfusion compared to 7 patients among those whodid not have TXA (1.2% vs. 11.12%, p = 0.02). The relative risk of 0.11 (95% confidence interval 0.01–0.86) indicates an89% reduction in the risk of requiring blood transfusion with TXA administration compared to no TXA.Conclusion: TXA is effective in reducing blood transfusion requirements for patients undergoing DAA THA.

Item Type: Article
Authors/Creators:Free, MD and Owen, DH and Pascoe, E and Allen, P and Yang, L and Harvie, P
Journal or Publication Title: HIP International
Publisher: Sage Publications Ltd.
ISSN: 1120-7000
DOI / ID Number: 10.1177/1120700018811310
Copyright Information:

Copyright 2018 The Authors

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