Open Access Repository

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework


Downloads per month over past year

Calabrese, EJ and Clarkson, TW and Cook, RR and Diamond, DM and Doolittle, DJ and Dorato, MA and Duke, SO and Feinendegen, L and Gardner, DE and Hart, RW and Hastings, KL and Bachmann, KA and Hayes, A and Hoffman, GR and Ives, JA and Jaworowski, Z and Johnson, TE and Jonas, WB and Kaminski, NE and Keller, JG and Klaunig, JE and Knudsen, TB and Bailer, AJ and Kozumbo, WJ and Lettieri, T and Liu, S and Maisseu, A and Maynard, KI and Masoro, EJ and McClellan, RO and Mehendale, HM and Mothersill, C and Newlin, DB and Bolger, PM and Nigg, HN and Oehme, FW and Phalen, RF and Philbert, MA and Rattan, SIS and Riviere, JE and Rodricks, J and Sapolsky, RM and Scott, BR and Seymour, C and Borak, J and Sinclair, DA and Smith-Sonneborn, J and Snow, ET and Spear, L and Stevenson, DE and Thomas, Y and Tubiana, M and Williams, GM and Mattson, MP and Cai, L and Cedergreen, N and Cherian, MG and Chiueh, CC (2007) Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicology and Applied Pharmacology, 222 (1). pp. 122-128. ISSN 0041-008X

[img] PDF
3990.pdf | Request a copy
Full text restricted


Many biological subdisciplines that regularly assess dose–response relationships have identified an evolutionarily conserved process in which
a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of
stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such
dose–response relationships. This situation has become problematic because the different terms describe a family of similar biological responses
(e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring
generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of
recommendations we believe can achieve greater conceptual harmony in dose–response terminology, as well as better understanding and
communication across the broad spectrum of biological disciplines.

Item Type: Article
Keywords: Hormesis; Adaptive response; Conditioning; Preconditioning; Postconditioning; Stress response; Dose–response; Biphasic; U-shaped
Journal or Publication Title: Toxicology and Applied Pharmacology
Publisher: Academic Press Inc Elsevier Science
Page Range: pp. 122-128
ISSN: 0041-008X
Identification Number - DOI: 10.1016/j.taap.2007.02.015
Additional Information:

The definitive version is available at

Date Deposited: 07 Apr 2008 14:16
Last Modified: 18 Nov 2014 03:34
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page