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Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework


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Calabrese, EJ, Clarkson, TW, Cook, RR, Diamond, DM, Doolittle, DJ, Dorato, MA, Duke, SO, Feinendegen, L, Gardner, DE, Hart, RW, Hastings, KL, Bachmann, KA, Hayes, A, Hoffman, GR, Ives, JA, Jaworowski, Z, Johnson, TE, Jonas, WB, Kaminski, NE, Keller, JG, Klaunig, JE, Knudsen, TB, Bailer, AJ, Kozumbo, WJ, Lettieri, T, Liu, S, Maisseu, A, Maynard, KI, Masoro, EJ, McClellan, RO, Mehendale, HM, Mothersill, C, Newlin, DB, Bolger, PM, Nigg, HN, Oehme, FW, Phalen, RF, Philbert, MA, Rattan, SIS, Riviere, JE, Rodricks, J, Sapolsky, RM, Scott, BR, Seymour, C, Borak, J, Sinclair, DA, Smith-Sonneborn, J, Snow, ET, Spear, L, Stevenson, DE, Thomas, Y, Tubiana, M, Williams, GM, Mattson, MP, Cai, L, Cedergreen, N, Cherian, MG and Chiueh, CC 2007 , 'Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework' , Toxicology and Applied Pharmacology, vol. 222, no. 1 , pp. 122-128 , doi: 10.1016/j.taap.2007.02.015.

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Many biological subdisciplines that regularly assess dose–response relationships have identified an evolutionarily conserved process in which
a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of
stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such
dose–response relationships. This situation has become problematic because the different terms describe a family of similar biological responses
(e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring
generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of
recommendations we believe can achieve greater conceptual harmony in dose–response terminology, as well as better understanding and
communication across the broad spectrum of biological disciplines.

Item Type: Article
Authors/Creators:Calabrese, EJ and Clarkson, TW and Cook, RR and Diamond, DM and Doolittle, DJ and Dorato, MA and Duke, SO and Feinendegen, L and Gardner, DE and Hart, RW and Hastings, KL and Bachmann, KA and Hayes, A and Hoffman, GR and Ives, JA and Jaworowski, Z and Johnson, TE and Jonas, WB and Kaminski, NE and Keller, JG and Klaunig, JE and Knudsen, TB and Bailer, AJ and Kozumbo, WJ and Lettieri, T and Liu, S and Maisseu, A and Maynard, KI and Masoro, EJ and McClellan, RO and Mehendale, HM and Mothersill, C and Newlin, DB and Bolger, PM and Nigg, HN and Oehme, FW and Phalen, RF and Philbert, MA and Rattan, SIS and Riviere, JE and Rodricks, J and Sapolsky, RM and Scott, BR and Seymour, C and Borak, J and Sinclair, DA and Smith-Sonneborn, J and Snow, ET and Spear, L and Stevenson, DE and Thomas, Y and Tubiana, M and Williams, GM and Mattson, MP and Cai, L and Cedergreen, N and Cherian, MG and Chiueh, CC
Keywords: Hormesis; Adaptive response; Conditioning; Preconditioning; Postconditioning; Stress response; Dose–response; Biphasic; U-shaped
Journal or Publication Title: Toxicology and Applied Pharmacology
Publisher: Academic Press Inc Elsevier Science
ISSN: 0041-008X
DOI / ID Number: 10.1016/j.taap.2007.02.015
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