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Adolescent exposure to high-dose estrogen and subsequent effects on lactation

Jordan, HL, Bruinsma, FJ, Thomson, RJ, Amir, LH, Werther, GA and Venn, AJ 2007 , 'Adolescent exposure to high-dose estrogen and subsequent effects on lactation' , Reproductive Toxicology, vol. 24, no. 3-4 , pp. 397-402 , doi:

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Treatment with high-dose estrogens has been used to reduce the adult height of tall girls for many years. Short-term side effects on the breast have been reported but there have been no studies to investigate whether there are long-term effects on lactation. This retrospective cohort study of 371 treated and 409 untreated women asked about breastfeeding history. After adjusting for maternal age at first live-birth, treated women (4.4%) were no more likely than untreated women (4.1%) to not commence breastfeeding (RR 1.13, 95% CI 0.50–2.52). After adjusting for age, there was no significant difference in the average duration of breastfeeding between treated (median 41.1 weeks) and untreated women (median 43.3 weeks) (p = 0.77) for all live-births. Treated women were not significantly more likely to report physiological reasons for stopping breastfeeding than untreated women. Women treated with high-dose estrogens during adolescence appeared to be no different to untreated women in their ability to lactate.

Item Type: Article
Authors/Creators:Jordan, HL and Bruinsma, FJ and Thomson, RJ and Amir, LH and Werther, GA and Venn, AJ
Keywords: Lactation; Breastfeeding; Hormones; Tall girls; Mammary gland; Diethylstilbesterol; Estrogen
Journal or Publication Title: Reproductive Toxicology
Publisher: Elsevier Inc
ISSN: 0890-6238
DOI / ID Number:
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