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Potential for endothelin-1-mediated impairment of contractile activity in hypertension


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Kolka, CM, Rattigan, S, Richards, SM and Clark, MG 2007 , 'Potential for endothelin-1-mediated impairment of contractile activity in hypertension' , Clinical and Experimental Physiology and Pharmacology, vol. 34, no. 3 , pp. 217-222 , doi: 10.1111/j.1440-1681.2007.04575.x.

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The present study examined the potential for reduced
exercise capacity observed in hypertensive patients as a result
of elevated levels of endothelin (ET)-1. We have previously
reported that ET-1 exerts low-dose stimulatory or high-dose
inhibitory effects on the metabolism of the rat isolated perfused
hindlimb from its vasoconstrictor activity.
Herein, we determined whether there are similar effects on
tension development by the rat isolated constant-flow hindlimb
during ET-1-mediated vasoconstriction.
The dose-dependent vasoconstrictor effects of ET-1 on
metabolism in contracting muscle were the same as those
observed previously in resting muscle. Highest concentrations of
ET-1 gave rise to a transient stimulation followed by a marked
inhibition of tension development, consistent with a decrease in
aerobic capacity of the muscle. The vasoconstriction due to the
higher doses of ET-1 was not dilated by electrical stimulation.
In conclusion, the biphasic nature of the actions of ET-1
suggests that although lower concentrations of ET-1 do not affect
exercise capacity, higher concentrations that may occur in
hypertension are inhibitory to metabolism and aerobic capacity
of muscle. The inhibitory effects of ET-1 appear to result from
enhanced functional shunting.

Item Type: Article
Authors/Creators:Kolka, CM and Rattigan, S and Richards, SM and Clark, MG
Keywords: endothelin, exercise, microcirculation, rats, regional blood flow, vasoconstriction.
Journal or Publication Title: Clinical and Experimental Physiology and Pharmacology
Publisher: Blackwell Publishing
ISSN: 0305-1870
DOI / ID Number: 10.1111/j.1440-1681.2007.04575.x
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