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Immunosuppressive and cytotoxic therapy for pulmonary sarcoidosis

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Paramothayan, PJ and Lasserson, TJ and Walters, EH (2007) Immunosuppressive and cytotoxic therapy for pulmonary sarcoidosis. Cochrane Database of Systematic Reviews, 2. pp. 1-28. ISSN 1469-493X

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Abstract

Sarcoidosis is a common, multi system, granulomatous disorder
with frequent lung involvement that can in some cases progress
to pulmonary fibrosis. The severity of the lung involvement is assessed
on the basis of the patient’s symptoms (particularly dyspnoea
and cough), changes on the chest x-ray (CXR) and on deteriorating
lung function. High resolution CT scans are now important
in differentiating sarcoid from other interstitial lung diseases.
Patientsmay also complain of systemic symptoms such as lethargy.
Involvement of other organs including liver, skin and brain is also
common in this group of patients. Oral corticosteroids are often
prescribed first in such cases. Immunosuppressives and cytotoxic
agents are also prescribed for those who do not respond to steroids
and show a progressive deterioration or to those who are unable
to tolerate steroids (steroid sparing agents).

Item Type: Article
Journal or Publication Title: Cochrane Database of Systematic Reviews
Publisher: Wiley-Liss, Div John Wiley & Sons Inc
Page Range: pp. 1-28
ISSN: 1469-493X
Identification Number - DOI: 10.1002/14651858.CD003536.pub2.
Additional Information:

Copyright © 2008 The Cochrane Collaboration. Published by JohnWiley & Sons, Ltd

Date Deposited: 07 Apr 2008 14:20
Last Modified: 18 Nov 2014 03:34
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