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Abstract

Poor sensitivity is considered to be one of the major limitations of electrophoretic separation methods, particularly when compared to traditional liquid chromatographic techniques. To address this issue, various in-line preconcentration techniques have been developed over the past 15 years, ranging in power and complexity, and there are now a number of well understood approaches routinely capable of providing a 10 000- to 100 000-fold increase in sensitivity, as well as several that can be pushed above a million. Furthermore, these have been achieved with particularly troublesome and often difficult samples, such as those having high salinity from a biological or environmental origin. This review will discuss the most common methods for improving the
sensitivity of CE, CEC and microchip version of these, with particular attention to those approaches developed over the last five years.

Item Type:	Article
Authors/Creators:	Breadmore, MC
Keywords:	Extraction; Focusing; Preconcentration; Stacking; Sweeping
Journal or Publication Title:	Electrophoresis
Publisher:	Wiley-VCH
ISSN:	0173-0835
DOI / ID Number:	10.1002/elps.200600463
Additional Information:	The original publication is available at http://www.interscience.wiley.com/
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