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Metallothionein expression by NG2 glial cells following CNS injury

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Chung, RS, Fung, SJ, Leung, YK, Walker, AK, McCormack, GH, Chuah, MI, Vickers, JC and West, AK 2007 , 'Metallothionein expression by NG2 glial cells following CNS injury' , Cellular and Molecular Life Sciences, vol. 64, No. 19-20 , pp. 2716-2722 , doi: 10.1007/s00018-007-7267-8.

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Abstract

Metallothionein (MT) expression is rapidly
up-regulated following CNS injury, and there is a
strong correlation between the presence or absence of
MTand improved or impaired (respectively) recovery
from such trauma.We now report that a distinct subset
of NG2-positive, GFAP-negative glial cells bordering
the injury tract express MT following focal injury to
the adult rat neocortex. To confirm the ability of these
NG2 glial cells to express MT, we have isolated and
cultured them and identified that they can expressMT
following stimulation with zinc. To investigate the
functional importance of MTexpression by NG2 glial
cells, we plated cortical neurons onto these cells and
found that expression of MTenhanced the permissivity
of NG2 glial cells to neurite outgrowth. Our data
suggest that expression of MT by NG2 glial cells may
contribute to the overall permissiveness of these cells
to axon regeneration.

Item Type: Article
Authors/Creators:Chung, RS and Fung, SJ and Leung, YK and Walker, AK and McCormack, GH and Chuah, MI and Vickers, JC and West, AK
Journal or Publication Title: Cellular and Molecular Life Sciences
Publisher: Birkhauser Verlag AG
ISSN: 1420-682X
DOI / ID Number: 10.1007/s00018-007-7267-8
Additional Information:

The original publication is available at www.springerlink.com

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