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The lack of effect of isoflavones on high-density lipoprotein cholesterol concentrations in adolescent boys: a 6-week randomised trial


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Dwyer, T, Hynes, K, Fryer, JL, Blizzard, CL and Dalais, FS 2007 , 'The lack of effect of isoflavones on high-density lipoprotein cholesterol concentrations in adolescent boys: a 6-week randomised trial' , Public Health Nutrition, vol. 11, no. 9 , pp. 955-962 , doi: 10.1017/S1368980007000869.

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Background: A substantial fall in high-density lipoprotein cholesterol (HDL-C)
during puberty in boys, but not girls, has been reported in Western populations.
The fall in boys is believed to be due to hormonal changes – androgens have
been shown to be associated with lower HDL-C, whereas oestrogens are associated
with higher HDL-C. The fall in HDL-C during puberty was not observed,
however, in a study of Moslem boys in Israel, nor in a group of Japanese boys. A
diet high in phyto-oestrogens may account for the lack of a fall in HDL-C in these
Objective: To examine the effect of dietary supplementation with phyto-oestrogens
on the HDL-C concentration of adolescent boys from a Western population. We
hypothesised that dietary supplementation of 50mg of the isoflavones daidzein
and genistein would produce a 12% higher HDL-C concentration than in controls
at the end of a 6-week intervention period.
Design: A randomised controlled trial.
Setting: Hellyer College in Burnie (Tasmania, Australia).
Subjects: Adolescent boys (aged 16–18 years) were recruited through a letter sent
to parents. A total of 132 eligible participants enrolled and five subjects withdrew
from the trial.
Results: No significant increase in HDL-C was observed in the treatment group
(–0.02 mmol l–1, standard error (SE)50.03, P50.53) or the placebo group
(0.05 mmol l–1, SE50.03, P50.11).
Conclusions: Factors other than isolated dietary isoflavones may be responsible
for the lack of fall in HDL-C during puberty in Japanese and Moslem boys.

Item Type: Article
Authors/Creators:Dwyer, T and Hynes, K and Fryer, JL and Blizzard, CL and Dalais, FS
Keywords: High-density lipoprotein cholesterol Phyto-oestrogens Isoflavones Adolescent boys Randomised controlled trial
Journal or Publication Title: Public Health Nutrition
Publisher: Cambridge University Press
ISSN: 1368-9800
DOI / ID Number: 10.1017/S1368980007000869
Additional Information:

8 pages article

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