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Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade

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du Bois, XF and Hsu, CW and Li, Yulin and Deng, C and Tan, YY and Huang, XF (2007) Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade. Journal of Neuroscience Research, 33 (7). pp. 1224-1231. ISSN 0360-4012

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Abstract

This study examined how perinatal phencyclidine
(PCP) treatment would affect dopamine D2 receptor
and dopamine transporter (DAT) binding at different stages
after treatment cessation. Female rat pups received injections of PCP (10 mg/kg, s.c.) or saline on postnatal day(PN)7, 9 and 11. D2 receptor and transporter binding was
examined at four time-points (PN12, 18, 32 and 96) following injections. PCP treatment altered D2 receptor
binding throughout development, with a final end-point of
22–33% decreased binding at adulthood in the nucleus
accumbens and caudate putamen (P\0.01, accompanied
by a small but significant increase in DAT binding in the
caudate putamen. Tyrosine hydroxylase mRNA expression
was also significantly increased by 25% (P\0.05) in the
ventral tegmental area of adult rats, suggesting that this
model may produce a long-term increase in dopamine
output. This study demonstrates that early insult to the
brain from NMDA receptor hypofunction alters the dopaminergic system at different stages of development.

Item Type: Article
Keywords: Brain development � NMDA receptor �Phencyclidine � Dopaminergic system
Journal or Publication Title: Journal of Neuroscience Research
Publisher: Wiley-Liss
Page Range: pp. 1224-1231
ISSN: 0360-4012
Identification Number - DOI: 10.1007/s11064-007-9571-y
Additional Information:

The original publication is available at www.springerlink.com

Date Deposited: 07 Apr 2008 14:29
Last Modified: 18 Nov 2014 03:35
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