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Influence of tDCS over right inferior frontal gyrus and pre-supplementary motor area on perceptual decision-making and response inhibition: A healthy ageing perspective

Fujiyama, H, Tan, J, Puri, R ORCID: 0000-0002-0231-1369 and Hinder, M ORCID: 0000-0002-5240-4790 2022 , 'Influence of tDCS over right inferior frontal gyrus and pre-supplementary motor area on perceptual decision-making and response inhibition: A healthy ageing perspective' , Neurobiology of Aging, vol. 109 , pp. 11-21 , doi: 10.1016/j.neurobiolaging.2021.09.014.

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Abstract

A wide body of literature suggests that transcranial direct current stimulation (tDCS) administered over the prefrontal cortex can improve executive function – including decision-making and inhibitory control – in healthy young adults. However, the effects of tDCS in older adults are largely unknown. Here, using a double-blind, sham-controlled approach, changes in a combined perceptual decision-making and inhibitory control task were assessed before and after the application of tDCS (1 mA, 20 minute) targeting the right inferior frontal gyrus (rIFG) or pre-supplementary motor area (preSMA) in 42 young (18–34 years) and 41 older (60–80 years) healthy adults. Compared to sham stimulation, anodal tDCS over the preSMA improved decision-making speed for both age groups. Furthermore, the inhibitory control performance of older and younger adults was improved by preSMA and rIFG stimulation, respectively. This study provides evidence that tDCS can improve both perceptual decision-making and inhibitory control in healthy older adults, with the causal role of the preSMA and rIFG regions in cognitive control appearing to vary as a function of healthy ageing.

Item Type: Article
Authors/Creators:Fujiyama, H and Tan, J and Puri, R and Hinder, M
Keywords: brain stimulation, inhibitory control, decision making, age-related decline, inhibitory control, stop signal task, transcranial direct current stimulation, inferior frontal gyrus, pre-supplementary motor area
Journal or Publication Title: Neurobiology of Aging
Publisher: Elsevier Science Inc
ISSN: 0197-4580
DOI / ID Number: 10.1016/j.neurobiolaging.2021.09.014
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© 2021 Elsevier Inc. All rights reserved

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