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Prognostic significance of long non-coding RNA five prime to XIST in various cancers

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Zhou, J, Chen, J, Chen, Z, Wu, G, Zhou, Z ORCID: 0000-0002-0835-8686, Wu, T, Wang, W, Luo, Y and Liu, T 2022 , 'Prognostic significance of long non-coding RNA five prime to XIST in various cancers' , BMC Cancer, vol. 22 , pp. 1-11 , doi: 10.1186/s12885-021-09161-0.

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Abstract

BackgroundTo observe the clinicopathological and prognostic value of long non-coding RNA five prime to X inactive specific transcript (lncFTX) in multiple tumors.MethodsEligible studies for lncFTX were identified by searching PubMed, Embase, Web of Science and Cochrane Library databases from inception to December 01, 2020. Stata 12.0 software was used to calculate the odds ratio (OR)/hazard ratio (HR) and 95% confidence interval (95% CI). We used The Cancer Genome Atlas (TCGA) dataset to further investigate the differential expression and prognostic value of lncFTX.ResultsWe included 11 studies involving a total of 1633 patients. The results showed that the expression of lncFTX was positively associated with advanced TNM stage (III-IV versus I-II) (OR = 2.30, 95% CI: 1.74–3.03, P ConclusionsThis study found that the expression of lncFTX was positively associated with advanced tumor node metastasis (TNM) stage, lymph nodes, distant metastasis and, cancer mortality, suggesting that lncFTX might be a potential prognostic biomarker for tumors.

Item Type: Article
Authors/Creators:Zhou, J and Chen, J and Chen, Z and Wu, G and Zhou, Z and Wu, T and Wang, W and Luo, Y and Liu, T
Keywords: LncRNA FTX, clinicopathological features, prognosis, meta-analysis, TCGA dataset
Journal or Publication Title: BMC Cancer
Publisher: Biomed Central Ltd
ISSN: 1471-2407
DOI / ID Number: 10.1186/s12885-021-09161-0
Copyright Information:

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, (https://creativecommons.org/licenses/by/4.0/) which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

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