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Translation of animal endocannabinoid models of PTSD mechanisms to humans: where to next?

Ney, LJ, Crombie, KM, Mayo, LM, Felmingham, KL, Bowser, T and Matthews, A ORCID: 0000-0003-2961-9125 2022 , 'Translation of animal endocannabinoid models of PTSD mechanisms to humans: where to next?' , Neuroscience and Biobehavioral Reviews, vol. 132 , pp. 76-91 , doi: 10.1016/j.neubiorev.2021.11.040.

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Abstract

The endocannabinoid system is known to be involved in mechanisms relevant to PTSD aetiology and maintenance, though this understanding is mostly based on animal models of the disorder. Here we review how human paradigms can successfully translate animal findings to human subjects, with the view that substantially increased insight into the effect of endocannabinoid signalling on stress responding, emotional and intrusive memories, and fear extinction can be gained using modern paradigms and methods for assessing the state of the endocannabinoid system in PTSD.

Item Type: Article
Authors/Creators:Ney, LJ and Crombie, KM and Mayo, LM and Felmingham, KL and Bowser, T and Matthews, A
Keywords: cannabinoids, endocannabinoids, posttraumatic stress disorder, stress, memory, fear conditioning, PTSD
Journal or Publication Title: Neuroscience and Biobehavioral Reviews
Publisher: Pergamon-Elsevier Science Ltd
ISSN: 0149-7634
DOI / ID Number: 10.1016/j.neubiorev.2021.11.040
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© 2021 Elsevier Ltd. All rights reserved.

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