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Abstract

Apnoea, a pause in respiration, is ubiquitous in preterm infants and are often associated with physiological instability, which may lead to longer-term adverse neurodevelopmental consequences. Despite current therapies aimed at reducing the apnoea burden, preterm infants continue to exhibit apnoeic events throughout their hospital admission. Bedside staff are frequently required to manually intervene with different forms of stimuli, with the aim of re-establishing respiratory cadence and minimizing the physiological impact of each apnoeic event. Such a reactive approach makes apnoea and its associated adverse consequences inevitable and places a heavy reliance on human intervention. Different approaches to improving apnoea management in preterm infants have been investigated, including the use of various sensory stimuli. Despite studies reporting sensory stimuli of various forms to have potential in reducing apnoea frequency, non-invasive intermittent positive pressure ventilation is the only automated stimulus currently used in the clinical setting for infants with persistent apnoeic events. We find that the development of automated closed-looped sensory stimulation systems for apnoea mitigation in preterm infants receiving non-invasive respiratory support is warranted, including the possibility of stimulation being applied preventatively, and in a multi-modal form.

Item Type:	Article
Authors/Creators:	Lim, KL and Cramer, SJE and te Pas, AB and Gale, TJ and Dargaville, PA
Keywords:	apnoea, preterm infant, mitigation, stimulus
Journal or Publication Title:	Pediatric Research
Publisher:	Int Pediatric Research Foundation
ISSN:	0031-3998
DOI / ID Number:	10.1038/s41390-021-01828-5
Copyright Information:	Copyright The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc
Related URLs:	Google Scholar: Gale, TJ UTAS Profile: Gale, TJ UTAS Profile: Dargaville, PA
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