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Repetitive Transcranial Magnetic Stimulation in the Treatment of Obsessive-Compulsive Disorder and Other Anxiety Disorders

Pridmore, S and Marcolin, MA and Ribeiro, CS and Mansur, CG (2007) Repetitive Transcranial Magnetic Stimulation in the Treatment of Obsessive-Compulsive Disorder and Other Anxiety Disorders. Advances in Biological Psychiatry, 23. pp. 124-133. ISSN 0378-7354

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Abstract

Repetitive transcranial magnetic stimulation (rTMS) is being investigated as a treatment of psychiatric disorders. This chapter reviews publications of the treatment of anxiety disorders: obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD) and panic disorder (PD). No definite conclusions can be reached as insufficient work has been completed. Many reports are single-case or small case studies and there have been few blind studies. There is no standardization of the site of stimulation or treatment parameters. OCD: there is some early evidence that 10-Hz stimulation of the left dorsolateral prefrontal cortex and right dorsolateral prefrontal cortex, and 1-Hz simultaneous stimulation of the left and right supplementary motor area may reduce symptoms. PTSD: one blind study suggests 10-Hz stimulation of the right dorsolateral prefrontal cortex may reduce core symptoms (reexperiencing, avoidance and hyperarousal). PD: 3 case studies have been published; 1 found that 1-Hz stimulation of the right dorsolateral prefrontal cortex reduced symptoms and response to cholecystokinin tetrapeptide challenge. Further work will clarify the role (if any) of rTMS in the treatment of these 3 disorders.

Item Type: Article
Journal or Publication Title: Advances in Biological Psychiatry
Publisher: S. Karger AG
Page Range: pp. 124-133
ISSN: 0378-7354
Identification Number - DOI: 10.1159/000101034
Date Deposited: 07 Apr 2008 14:45
Last Modified: 18 Dec 2008 01:15
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