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Seasonal chemical evaluation of Miconia chamissois Naudin from Brazilian savanna


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Ferreira, JF, Lopez, MHM, Gomes, JVD, Matrins, DHN, Fagg, CW, Magalhaes, PO, Davies, NW ORCID: 0000-0002-9624-0935, Silviera, D and Fonseca-Bazzo, YM 2022 , 'Seasonal chemical evaluation of Miconia chamissois Naudin from Brazilian savanna' , Molecules, vol. 27, no. 3 , pp. 1-16 , doi: 10.3390/molecules27031120.

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Miconia chamissois Naudin is a species from the Cerrado, which is being increasingly researched for its therapeutic potential. The aim of this study was to obtain a standardized extract and to evaluate seasonal chemical variations. Seven batches of aqueous extracts from leaves were produced for the standardization. These extracts were evaluated for total solids, polyphenol (TPC) and flavonoid content (TFC), vitexin derivative content, antioxidant activity; thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) profiles were generated. For the seasonal study, leaves were collected from five different periods (May 2017 to August 2018). The results were correlated with meteorological data (global radiation, temperature, and rainfall index). Using chromatographic and spectroscopic techniques, apigenin C-glycosides (vitexin/isovitexin) and derivatives, luteolin C-glycosides (orientin/isoorientin) and derivatives, a quercetin glycoside, miconioside B, matteucinol-7-O-β-apiofuranosyl (1 → 6) -β-glucopyranoside, and farrerol were identified. Quality parameters, including chemical marker quantification by HPLC, and biological activity, are described. In the extract standardization process, all the evaluated parameters showed low variability. The seasonality study revealed no significant correlations (p M. chamissois at any time of the year without significant differences in composition.

Item Type: Article
Authors/Creators:Ferreira, JF and Lopez, MHM and Gomes, JVD and Matrins, DHN and Fagg, CW and Magalhaes, PO and Davies, NW and Silviera, D and Fonseca-Bazzo, YM
Keywords: Brazilian savanna, Miconia chamissois, flavonoids, antioxidants, isovitexin, miconioside B
Journal or Publication Title: Molecules
Publisher: Molecular Diversity Preservation International
ISSN: 1420-3049
DOI / ID Number: 10.3390/molecules27031120
Copyright Information:

Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons 4.0 International (CC BY 4.0) license (

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