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Abstract

Prolonged sitting contributes to cardiovascular disease (CVD) risk. The underlying mechanisms are unknown, but may include changes in arterial function and vasoactive mediators. We examined the effects of prolonged unbroken sitting, relative to regular active interruptions to sitting time, on arterial function in adults at increased CVD risk. In a randomized crossover trial, 19 sedentary overweight/obese adults (mean±SD 57±12 yrs), completed two laboratory-based conditions: five hours uninterrupted sitting (SIT) and; five hours sitting interrupted every 30 minutes by three minutes of simple resistance activities (SRA). Femoral artery function (flow mediated dilation; FMD), blood flow and shear rate were measured at zero hour, 30 minutes, one, two and five hours. Brachial FMD was assessed at zero and five hours. Plasma was collected hourly for measurement of endothelin-1 (ET-1), nitrates/nitrites, vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). There was a significant decline in femoral artery FMD, averaged over five hours in the SIT condition, relative to SRA (p0.05 for all). Five hours of prolonged sitting, relative to regular interruptions to sitting time, impaired femoral artery vasodilator function and increased circulating ET-1 in overweight/obese adults. There is the need to build on this evidence beyond acute observations to better understand the potential longer-term vascular-related consequences of prolonged sitting.

Item Type:	Article
Authors/Creators:	Climie, RE and Wheeler, MJ and Grace, M and Lambert, E and Cohen, N and Owen, N and Kingwell, B and Dunstan, DW and Green, DJ
Keywords:	obesity, arteries, blood flow, blood pressure, sedentary lifestyle, vascular ageing, sitting
Journal or Publication Title:	Journal of Applied Physiology
Publisher:	Amer Physiological Soc
ISSN:	8750-7587
DOI / ID Number:	https://doi.org/10.1152/japplphysiol.00544.2018
Copyright Information:	Copyright © 2018 the American Physiological Society
Item Statistics:	View statistics for this item

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