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Abstract

Objectives: To understand if pregnancy unmasks previously silent cardiovascular (CV) adverse factors, or initiates lasting injury.Methods: Pre-pregnancy and during pregnancy CV risk factors (blood pressure, fasting lipids, and glucose) from 296 women belonging to studies in the International Childhood Cardiovascular Cohort (i3C) Consortium, a group of studies assessing the relationship between child and adolescent CV risk factors and adult outcomes, were used. Correlation coefficients between the pre- and during pregnancy measures were calculated, and the mean difference between the measures was modeled with adjustment for age, body mass index, race, smoking, and study.Results: Measures were strongly correlated at pre- and during-pregnancy visits (p Conclusions: Pre- and during-pregnancy CV risk factors are moderately well correlated. This may indicate that susceptible women enter pregnancy with higher risk rather than pregnancy inducing new vascular or metabolic effects.

Item Type:	Article
Authors/Creators:	Harville, EW and Crook, CE and Bazzano, LA and Woo, JG and Burns, TL and Raitakari, O and Urbina, EM and Venn, A and Jacobs, DR and Steinberger, J and Sinaiko, A and Dwyer, T and Juonala, M
Keywords:	blood pressure, cholesterol, glucose, pregnancy
Journal or Publication Title:	Journal of Obstetrics and Gynaecology Research
Publisher:	University of Tokyo Press
ISSN:	1341-8076
DOI / ID Number:	https://doi.org/10.1111/jog.14971
Copyright Information:	© 2021 Japan Society of Obstetrics and Gynecology
Related URLs:	Google Scholar: Venn, A UTAS Profile: Venn, A
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