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Cardiovascular risk factors before and during pregnancy: Does pregnancy unmask or initiate risk?

Harville, EW, Crook, CE, Bazzano, LA, Woo, JG, Burns, TL, Raitakari, O, Urbina, EM, Venn, A ORCID: 0000-0001-7090-1398, Jacobs, DR, Steinberger, J, Sinaiko, A, Dwyer, T and Juonala, M 2021 , 'Cardiovascular risk factors before and during pregnancy: Does pregnancy unmask or initiate risk?' , Journal of Obstetrics and Gynaecology Research, vol. 47, no. 11 , 3849–3856 , doi:

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Objectives: To understand if pregnancy unmasks previously silent cardiovascular (CV) adverse factors, or initiates lasting injury.Methods: Pre-pregnancy and during pregnancy CV risk factors (blood pressure, fasting lipids, and glucose) from 296 women belonging to studies in the International Childhood Cardiovascular Cohort (i3C) Consortium, a group of studies assessing the relationship between child and adolescent CV risk factors and adult outcomes, were used. Correlation coefficients between the pre- and during pregnancy measures were calculated, and the mean difference between the measures was modeled with adjustment for age, body mass index, race, smoking, and study.Results: Measures were strongly correlated at pre- and during-pregnancy visits (p Conclusions: Pre- and during-pregnancy CV risk factors are moderately well correlated. This may indicate that susceptible women enter pregnancy with higher risk rather than pregnancy inducing new vascular or metabolic effects.

Item Type: Article
Authors/Creators:Harville, EW and Crook, CE and Bazzano, LA and Woo, JG and Burns, TL and Raitakari, O and Urbina, EM and Venn, A and Jacobs, DR and Steinberger, J and Sinaiko, A and Dwyer, T and Juonala, M
Keywords: blood pressure, cholesterol, glucose, pregnancy
Journal or Publication Title: Journal of Obstetrics and Gynaecology Research
Publisher: University of Tokyo Press
ISSN: 1341-8076
DOI / ID Number:
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© 2021 Japan Society of Obstetrics and Gynecology

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