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An omega 3 fatty acid supplemented diet was not associated with enhanced survival in maintenance haemodialysis: the Fish and Fruit Study
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ORCID: 0000-0002-9589-0071, Snelling, P, Hall, H, Cass, A and O'Dea, K 2020
, 'An omega 3 fatty acid supplemented diet was not associated with enhanced survival in maintenance haemodialysis: the Fish and Fruit Study'
, Renal Society of Australasia Journal, vol. 16, no. 2
, pp. 69-82
, doi: https://doi.org/10.33235/rsaj.16.2.69-82.
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Abstract
Background: Aboriginal people requiring haemodialysis experience high cardiovascular mortality. Dietary interventions have uncertain effects on mortality and cardiovascular events in people with end-stage kidney disease (ESKD).Aim: To determine if a dietary intervention of fish and fruit would decrease all-cause and cardiovascular mortality in Aboriginal people requiring haemodialysis.Methods: A randomised dietary intervention of 300gm fish and five portions of fruit spaced over three dialysis treatments per week versus usual renal diet. Blood concentrations of omega-3 and omega-6 polyunsaturated fatty acids (n-3 PUFA and n-6 PUFA respectively) were recorded over a 12-month period.Results: The mean age of the 151 randomised patients was 53 years; 42% were males, 94% of Aboriginal people and 74% with diabetes. There was no significant difference in n-3 PUFA concentration over the follow-up. The cardiovascular mortality rate was not different between the intervention and control group assessed at 2.1 years follow-up (3.7 v 4.3%, p=0.92), or at 5.0 years follow-up (19.7% v 21.8%, p=0.93).Conclusions: The 12-month diet intervention including fish and fruit meal supplementation did not provide a survival advantage in patients with very low baseline n-3:n-6 PUFA ratio.
| Item Type: | Article |
|---|---|
| Authors/Creators: | Barzi, F and Hughes, JT and Singh, G and Lawton, P and Coffey, P and Jose, M and Snelling, P and Hall, H and Cass, A and O'Dea, K |
| Keywords: | haemodialysis, diet, aboriginal, mortality, cardiovascular disease, chronic kidney disease, dialysis, end-stage kidney disease, cardiovascular |
| Journal or Publication Title: | Renal Society of Australasia Journal |
| Publisher: | Renal Society of Australasia |
| ISSN: | 2208-4088 |
| DOI / ID Number: | https://doi.org/10.33235/rsaj.16.2.69-82 |
| Copyright Information: | Copyright 2020 Renal Society of Australasia |
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