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Modulation of ion transport across plant membranes by polyamines: understanding specific modes of action under stress

Pottosin, I, Olivas-Aguirre, M, Dobrovinskaya, O, Zepeda-Jazo, I and Shabala, S ORCID: 0000-0003-2345-8981 2021 , 'Modulation of ion transport across plant membranes by polyamines: understanding specific modes of action under stress' , Frontiers in Plant Science, vol. 11 , doi: https://doi.org/10.3389/fpls.2020.616077.

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Abstract

This work critically discusses the direct and indirect effects of natural polyamines and their catabolites such as reactive oxygen species and γ-aminobutyric acid on the activity of key plant ion-transporting proteins such as plasma membrane H+ and Ca2+ ATPases and K+-selective and cation channels in the plasma membrane and tonoplast, in the context of their involvement in stress responses. Docking analysis predicts a distinct binding for putrescine and longer polyamines within the pore of the vacuolar TPC1/SV channel, one of the key determinants of the cell ionic homeostasis and signaling under stress conditions, and an additional site for spermine, which overlaps with the cytosolic regulatory Ca2+-binding site. Several unresolved problems are summarized, including the correct estimates of the subcellular levels of polyamines and their catabolites, their unexplored effects on nucleotide-gated and glutamate receptor channels of cell membranes and Ca2+-permeable and K+-selective channels in the membranes of plant mitochondria and chloroplasts, and pleiotropic mechanisms of polyamines’ action on H+ and Ca2+ pumps.

Item Type: Article
Authors/Creators:Pottosin, I and Olivas-Aguirre, M and Dobrovinskaya, O and Zepeda-Jazo, I and Shabala, S
Keywords: abiotic stress, Ca2+ ATPase, polyamine, vacuole, TPC1, H+ ATPase, ion channel, organelle
Journal or Publication Title: Frontiers in Plant Science
Publisher: Frontiers Research Foundation
ISSN: 1664-462X
DOI / ID Number: https://doi.org/10.3389/fpls.2020.616077
Copyright Information:

Copyright © 2021 Pottosin, Olivas-Aguirre, Dobrovinskaya, Zepeda-Jazo and Shabala. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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