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Integrating pharmacy and registry data strengthens clinical assessments of patient adherence


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Serhal, S, Armour, C, Billot, L, Krass, I, Emmerton, L, Saini, B, Bosnic-Anticevich, S, Bereznicki, B ORCID: 0000-0001-8463-4817, Bereznicki, L ORCID: 0000-0003-3974-3437, Shan, S and Campain, A 2022 , 'Integrating pharmacy and registry data strengthens clinical assessments of patient adherence' , Frontiers in Pharmacology, vol. 13 , pp. 1-13 , doi: 10.3389/fphar.2022.869162.

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Background:Accurate clinical assessment of patient adherence using reliable and valid measures is essential in establishing the presence of adherence issues and support practices for pharmacists.Objective:This investigation aims to conduct a novel assessment of patient adherence to asthma controller therapy by combining 1) patient-specific dosage data found in pharmacy dispensing data with 2) centrally collected administrative claims records, to determine the added value of using both sources of data.Methods:A total of 381 clinically uncontrolled asthma patients, from 95 community pharmacies across three Australian States were recruited and provided consent for the retrieval of their claims records and pharmacy dispensing data. Patients were stratified as multiple or single pharmacy users and adherence scores were calculated via the proportion of days covered (PDC) method using 1) patient claims records, 2) patient pharmacy dispensing data, and 3) combined claims records and pharmacy dispensing data. Cohort and subgroup adherence estimates were then compared.Results:Low levels of adherence were evident amongst the cohort irrespective of the data source used. PDC estimates based on claims records alone or combined claims records and pharmacy dispensing data were significantly higher than estimates based on pharmacy dispensing data for the total cohort (56%, 52%, 42% respectively, p p p p Conclusion:Access to routine collected data increases clinical acuity over patient adherence to asthma controller medications and is a valuable resource for health care professionals. A policy of secure accessibility of such data at the patient-pharmacist or patient-GP interface may allow real-time intervention and assist in decision making across numerous therapeutic areas.

Item Type: Article
Authors/Creators:Serhal, S and Armour, C and Billot, L and Krass, I and Emmerton, L and Saini, B and Bosnic-Anticevich, S and Bereznicki, B and Bereznicki, L and Shan, S and Campain, A
Keywords: asthma, medication adherence, data linkage, pharmacy, primary care, routinely collected data, pharmacy refill data, pharmaceutical benefits scheme
Journal or Publication Title: Frontiers in Pharmacology
Publisher: Frontiers Research Foundation
ISSN: 1663-9812
DOI / ID Number: 10.3389/fphar.2022.869162
Copyright Information:

Copyright © 2022 Serhal, Armour, Billot, Krass, Emmerton, Saini, Bosnic-Anticevich, Bereznicki, Bereznicki, Shan and Campain. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License ( The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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