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Abstract

Aim:Trends in the incidence of adverse drug reaction (ADR)–related hospitalizations have been studied in the general population, but not specifically in people with dementia. This study aimed to investigate trends in the incidence of ADR-related hospitalizations among people with dementia, and identify the most commonly implicated drugs and diagnoses in these admissions.Methods:This study utilized the administrative data of all adults admitted to the four major public hospitals of Tasmania, Australia, with a primary or secondary diagnosis of dementia from July 2010 to December 2019. ADR-related hospitalizations were identified by using diagnosis-based and external cause codes. The Cochran–Armitage test was used to examine trends in the incidence of ADR-related hospitalizations.Results:Of the 7552 people with dementia admitted to the hospital at least once within the study period, 1775 (23.5%) experienced at least one ADR-related hospitalization. The estimated annual incidence of ADR-related hospitalizations increased 18% (1484–1760 per 100,000 population with dementia, p for trend versus 5 days and 11% versus 6.7%, respectively; p Conclusion:The annual incidence of ADR-related hospitalizations in people with dementia increased between 2010 and 2019. Antithrombotics were the most commonly implicated drug class. The ADR-related hospitalizations were associated with increased length of stay and greater mortality.

Item Type:	Article
Authors/Creators:	Zaidi, AS and Peterson, GM and Bereznicki, LRE and Curtain, CM and Salahudeen, MS
Keywords:	ADR, adverse drug reactions, dementia, drug-related, elderly, hospital admission, hospitalization, re-admission, trends
Journal or Publication Title:	Therapeutic Advances in Drug Safety
Publisher:	Sage Publications
ISSN:	2042-0994
DOI / ID Number:	https://doi.org/10.1177/20420986221080796
Copyright Information:	Copyright 2020 The Authors. Licensed under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/
Related URLs:	UTAS Profile: Peterson, GM Google Scholar: Bereznicki, LRE UTAS Profile: Bereznicki, LRE Google Scholar: Curtain, CM UTAS Profile: Curtain, CM Google Scholar: Salahudeen, MS
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