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Abstract

In healthy and overweight/obese adults, interrupting prolonged sitting with activity bouts mitigates impairment in vascular function. However, it is unknown whether these benefits extend to those with type 2 diabetes (T2D), nor whether an optimal frequency of activity interruptions exist. We examined the acute effects on vascular function in T2D of interrupting prolonged sitting with simple resistance activities (SRA) at different frequencies. In a randomized crossover trial, 24 adults with T2D (35−70 yr) completed three 7-h conditions: 1) uninterrupted sitting (SIT), 2) sitting with 3-min bouts of SRA every 30 min (SRA3), and 3) sitting with 6 min bouts of SRA every 60 min (SRA6). Femoral artery flow-mediated dilation (FMD), resting shear rate, blood flow, and endothelin-1 were measured at 0, 1, 3.5, 4.5, and 6.5–7 h. Mean femoral artery FMD over 7 h was significantly higher in SRA3 (4.1 ± 0.3%) compared with SIT (3.7 ± 0.3%, P = 0.04) but not in SRA6. Mean resting femoral shear rate over 7 h was increased significantly for SRA3 (45.3 ± 4.1/s, P P

Item Type:	Article
Authors/Creators:	Taylor, FC and Dunstan, DW and Homer, AR and Dempsey, PC and Kingwell, BA and Climie, RE and Owen, N and Cohen, ND and Larsen, RN and Grace, M and Eikelis, N and Wheeler, MJ and Townsend, MK and Maniar, N and Green, DJ
Keywords:	type 2 diabetes, vascular ageing, arteries, blood flow, sedentary behavior
Journal or Publication Title:	American Journal of Physiology. Heart and Circulatory Physiology
Publisher:	American Physiological Society
ISSN:	1522-1539
DOI / ID Number:	https://doi.org/10.1152/ajpheart.00422.2020
Copyright Information:	Copyright 2021 the American Physiological Society
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