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The toxicology and metabolism of chlorothalonil in fish. 4. Zinc co-exposure and the significance of metallothionein in detoxication in Salmo gairdneri .

Davies, PE 1985 , 'The toxicology and metabolism of chlorothalonil in fish. 4. Zinc co-exposure and the significance of metallothionein in detoxication in Salmo gairdneri .' , Aquatic Toxicology, vol. 7, No. 4 , pp. 301-306 .

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Abstract

Rainbow trout, Salmo gairdneri , were subjected to various regimes of exposure to zinc (0.36 mg/l) and super(14)C-chlorothalonil ( super(14)C-TCIN, 10 mu g/l). Gel column chromatography of hepatic cytosol after exposures showed no binding of super(14)C-TCIN to metallothionein proteins with or without pre-exposure or with coexposure to zinc. super(14)C-TCIN did not induce the production of metallothionein with or without 96 h preexposure to 0.36 mg/l zinc, whereas induction did occur with zinc coexposure over 156 h. super(14)C-TCIN exposure did not affect cytosolic zinc levels, but exposure to zinc did reduce the level of cytosolic super(14)C-TCIN over the observed protein molecular weight range. It appears that metallothionein does not play a significant role in TCIN detoxication at this sublethal exposure level.

Item Type: Article
Authors/Creators:Davies, PE
Keywords: fungicides; toxicity; synergism; zinc; toxicity tests; fish physiology; animal metabolism
Journal or Publication Title: Aquatic Toxicology
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