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Cardiovascular health at age five years: distribution, determinants and association with neurodevelopment

Climie, RE, Tafflet, M, van Stolen, T, de Lauzon-Guillain, Blandine, Bernard, JY, Dargent-Molina, P, Plancoulaine, S, Lioret, S, Jouven, X, Charles, MA, Heude, B and Empana, JP 2022 , 'Cardiovascular health at age five years: distribution, determinants and association with neurodevelopment' , Frontiers in Pediatrics , doi:

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Background Early childhood may represent an opportune time to commence primordial prevention of cardiovascular disease (CVD, i.e. prevention of risk factors onset) but epidemiological evidence is scarce. We aimed to examine the distribution and parental and early life determinants of ideal cardiovascular health (CVH) in children up to five years and to compare the level of cognitive development between children with and without ideal CVH at age five. Methods Using data from the EDEN study, a French population-based mother-child cohort study, CVH was examined in children at five years of age based on the American Heart Association CVH metrics (ideal body mass index, physical activity, diet, blood pressure, cholesterol and glucose levels and passive smoking, considered in sensitivity analysis only). Children were categorized as having ideal (5-6 ideal metrics) or non-ideal CVH (Results Among the 566 children (55% boys), only 34% had ideal CVH. In fully adjusted logistic regression, boys compared to girls (OR=1.77, 95% CI1.13-2.78), children with intermediate (1.77, 1.05-2.98) or ideal (2.58, 1.38-4.82) behavioral CVH at age three and children who spent ConclusionThis study highlights that only a third of children aged five had ideal CVH, identified modifiable determinants of ideal CVH and is suggestive of an association between CVH and neurodevelopment at a young age.

Item Type: Article
Authors/Creators:Climie, RE and Tafflet, M and van Stolen, T and de Lauzon-Guillain, Blandine and Bernard, JY and Dargent-Molina, P and Plancoulaine, S and Lioret, S and Jouven, X and Charles, MA and Heude, B and Empana, JP
Keywords: childhood, determinants, neurodevelopment, primordial prevention, cardiovascular health
Journal or Publication Title: Frontiers in Pediatrics
Publisher: Frontiers Research Foundation
ISSN: 2296-2360
DOI / ID Number:
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Copyright © 2022 Climie, Tafflet, Sloten, Lauzon-Guillain, Bernard, Dargent-Molina, Plancoulaine, Lioret, Jouven, Charles, Heude and Empana. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License ( The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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