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The toxicology and metabolism of chlorothalonil in fish. 3. Metabolism, enzymatics and detoxication in Salmo spp. and Galaxias spp.

Davies, PE 1985 , 'The toxicology and metabolism of chlorothalonil in fish. 3. Metabolism, enzymatics and detoxication in Salmo spp. and Galaxias spp.' , Aquatic Toxicology, vol. 7, no. 4 , pp. 277-299 .

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Abstract

Hepatic glutathione S-transferase (GST) activity towards chlorothalonil, tetrachloro-isophthalonitrile (TCIN), was established for the five fish species: Salmo gairdneri, S. trutta, Galaxias maculatus, G. truttaceus and G. auratus . Low level exposure to TCIN was found to induce higher GST activity in G. maculatus, G. truttaceus and S. gairdneri . Significant decreases occurred in liver thiol levels of fish when exposed to varying concentrations of TCIN for 96 h without feeding. Liver GSH levels increased in S. gairdneri exposed to 10 mu g/l over 96 h with feeding. A marked increase in GST activity was observed during 96 h exposure to 10 mu g/l. No significant changes in the activity of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) were observed during exposure to 10 mu g/l TCIN in vivo. A transient decrease in activity was observed during exposure to 30 mu g/l TCIN.

Item Type: Article
Authors/Creators:Davies, PE
Keywords: fungicides, enzymatic activity, toxicity tests, sublethal effects, Salmo, Galaxias, Salmo trutta, Galaxias maculatus, Galaxias truttaceus
Journal or Publication Title: Aquatic Toxicology
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