Open Access Repository

Effects of chemical composition on the lung cell response to coal particles: Implications for coal workers' pneumoconiosis

Downloads

Downloads per month over past year

Song, Y ORCID: 0000-0002-8178-5641, Southam, K ORCID: 0000-0003-3171-6928, Beamish, BB and Zosky, GR ORCID: 0000-0001-9039-0302 2022 , 'Effects of chemical composition on the lung cell response to coal particles: Implications for coal workers' pneumoconiosis' , Respirology , doi: 10.1111/resp.14246.

[img]
Preview
PDF (Online first)
149950 - Effect...pdf | Download (1MB)

| Preview

Abstract

Background and objectiveCoal mine dust has a complex and heterogeneous chemical composition. It has been suggested that coal particle chemistry plays a critical role in determining the pathogenesis of coal workers' pneumoconiosis (CWP). In this study, we aimed to establish the association between the detrimental cellular response and the chemical composition of coal particles. MethodsWe sourced 19 real-world coal samples. Samples were crushed prior to use to minimize the impact of particle size on the response and to ensure the particles were respirable. Key chemical components and inorganic compounds were quantified in the coal samples. The cytotoxic, inflammatory and pro-fibrotic responses in epithelial cells, macrophages and fibroblasts were assessed following 24 h of exposure to coal particles. Principal component analysis (PCA) and stepwise regression were used to determine which chemical components of the coal particles were associated with the cell response. ResultsThe cytotoxic, inflammatory and pro-fibrotic response varied considerably between coal samples. There was a high level of collinearity in the cell responses and between the chemical compounds within the coal samples. PCA identified three factors that explained 75% of the variance in the cell response. Stepwise multiple regression analysis identified K2O (p 2O3 (p = 0.011) as significant predictors of cytotoxicity and cytokine production, respectively. ConclusionOur data clearly demonstrate that the detrimental cellular effects of exposure to coal mine dusts are highly dependent on particle chemistry. This has implications for understanding the pathogenesis of CWP.

Item Type: Article
Authors/Creators:Song, Y and Southam, K and Beamish, BB and Zosky, GR
Keywords: coal chemistry, coal workers' pneumoconiosis, cytotoxicity, fibroblast response, inflammatory response
Journal or Publication Title: Respirology
Publisher: Wiley-Blackwell Publishing Asia
ISSN: 1323-7799
DOI / ID Number: 10.1111/resp.14246
Copyright Information:

© 2022 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology. This is an open access article under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/) which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Related URLs:
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP