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The effect of insulin on response to intravitreal anti-VEGF injection in diabetic macular edema in type 2 diabetes mellitus

Gurung, RL, Fitzgerald, LM ORCID: 0000-0002-6882-2698, Liu, E, McComish, BJ ORCID: 0000-0003-1940-0007, Kaidonis, G, Ridge, B, Hewitt, AW ORCID: 0000-0002-5123-5999, Vote, BJT, Verma, N, Craig, JE and Burdon, KP ORCID: 0000-0001-8217-1249 2022 , 'The effect of insulin on response to intravitreal anti-VEGF injection in diabetic macular edema in type 2 diabetes mellitus' , BMC Ophthalmology, vol. 22 , p. 94 , doi:

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ObjectivesTo assess whether insulin therapy impacts the effectiveness of anti-vascular endothelial growth factor (anti-VEGF) injection for the treatment of diabetic macular edema (DME) in type 2 diabetes mellitus.MethodsThis was a retrospective multi-center analysis. The best-corrected visual acuity (BCVA) at 12 months, BCVA change, central macular thickness (CMT), CMT change, and cumulative injection number were compared between the insulin and the oral hypoglycemic agent (OHA) groups.ResultsThe mean final BCVA and CMT improved in both the insulin (N = 137; p p N = 61; p = 0.199; p p = 0.263), BCVA change (p = 0.184), final CMT (p = 0.741), CMT change (p = 0.458), and the cumulative injections received (p = 0.594). The results were comparable between the two groups when stratified by baseline vision (p > 0.05) and baseline HbA1c (p > 0.05).ConclusionInsulin therapy does not alter treatment outcomes for anti-VEGF therapy in DME.

Item Type: Article
Authors/Creators:Gurung, RL and Fitzgerald, LM and Liu, E and McComish, BJ and Kaidonis, G and Ridge, B and Hewitt, AW and Vote, BJT and Verma, N and Craig, JE and Burdon, KP
Keywords: diabetic macular edema, anti-VEGF, insulin, visual acuity, central macular thickness, diabetic retinopathy, treatment outcomes
Journal or Publication Title: BMC Ophthalmology
Publisher: BioMed Central Ltd
ISSN: 1471-2415
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© 2022. The Authors. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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