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Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study

Simic, M, Harmer, AR, Agaliotis, M ORCID: 0000-0002-3691-2234, Nairn, L, Bridgett, L, March, L, Votrubec, M, Edmonds, J, Woodward, M, Day, R and Fransen, M 2021 , 'Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study' , Arthritis Research and Therapy, vol. 23 , doi:

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Background:The aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over 1 to 2 years in people with painful medial knee osteoarthritis.Methods:A longitudinal study was conducted within a randomised controlled trial, the "Long-term Evaluation of Glucosamine Sulfate" (LEGS study). Recruitment occurred in 2007-2009, with 1- and 2-year follow-up assessments by blinded assessors. Community-dwelling people with chronic knee pain (≥4/10) and medial tibiofemoral narrowing (but retaining >2mm medial joint space width) on radiographs were recruited. From 605 participants, follow-up data were available for 498 (82%, mean [sd] age 60 [8] years). Risk factors evaluated at baseline were pain, physical function, use of non-steroidal anti-inflammatory drugs (NSAIDs), statin use, not meeting physical activity guidelines, presence of Heberden's nodes, history of knee surgery/trauma, and manual occupation. Multivariable logistic regression analysis was conducted adjusting for age, sex, obesity, high blood pressure, allocation to glucosamine and chondroitin treatment, and baseline structural disease severity (Kellgren and Lawrence grade, joint space width, and varus alignment). Radiographic osteoarthritis progression was defined as joint space narrowing ≥0.5mm over 1 to 2 years (latest follow-up used where available).Results:Radiographic osteoarthritis progression occurred in 58 participants (12%). Clinical factors independently associated with radiographic progression were the use of NSAIDs, adjusted odds ratios (OR) and 95% confidence intervals (CI) 2.05 (95% CI 1.1 to 3.8), and not meeting physical activity guidelines, OR 2.07 (95% CI 0.9 to 4.7).Conclusions:Among people with mild radiographic knee osteoarthritis, people who use NSAIDs and/or do not meet physical activity guidelines have a greater risk of radiographic osteoarthritis progression.

Item Type: Article
Authors/Creators:Simic, M and Harmer, AR and Agaliotis, M and Nairn, L and Bridgett, L and March, L and Votrubec, M and Edmonds, J and Woodward, M and Day, R and Fransen, M
Keywords: osteoarthritis, longitudinal studies, knee, glucosamine
Journal or Publication Title: Arthritis Research and Therapy
Publisher: BioMed Central Ltd.
ISSN: 1478-6354
DOI / ID Number:
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© 2021. The Authors. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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