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Adipose stromal/stem cell-derived extracellular vesicles: potential next-generation anti-obesity agents

Zuccarini, M, Giuliani, P, Di Liberto, V, Frinchi, M, Caciagli, F, Caruso, V ORCID: 0000-0002-0523-6149, Ciccarelli, R, Mudo, G and Di Iorio, P 2022 , 'Adipose stromal/stem cell-derived extracellular vesicles: potential next-generation anti-obesity agents' , International Journal of Molecular Sciences, vol. 23, no. 3 , pp. 1-17 , doi:

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Over the last decade, several compounds have been identified for the treatment of obesity. However, due to the complexity of the disease, many pharmacological interventions have raised concerns about their efficacy and safety. Therefore, it is important to discover new factors involved in the induction/progression of obesity. Adipose stromal/stem cells (ASCs), which are mostly isolated from subcutaneous adipose tissue, are the primary cells contributing to the expansion of fat mass. Like other cells, ASCs release nanoparticles known as extracellular vesicles (EVs), which are being actively studied for their potential applications in a variety of diseases. Here, we focused on the importance of the contribution of ASC-derived EVs in the regulation of metabolic processes. In addition, we outlined the advantages/disadvantages of the use of EVs as potential next-generation anti-obesity agents.

Item Type: Article
Authors/Creators:Zuccarini, M and Giuliani, P and Di Liberto, V and Frinchi, M and Caciagli, F and Caruso, V and Ciccarelli, R and Mudo, G and Di Iorio, P
Keywords: obesity, weight loss, metabolic disease/syndrome, extracellular vesicles, adipose tissue, adipose stromal/stem cells (ASCs)
Journal or Publication Title: International Journal of Molecular Sciences
Publisher: Molecular Diversity Preservation International
ISSN: 1422-0067
DOI / ID Number:
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© 2022. The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License ( The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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