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Abstract

ImportanceLimited studies have investigated the association between statin use and progression of arterial stiffness, a key player in the pathophysiology of cardiovascular disease.ObjectiveTo examine the association between statin use and progression of arterial stiffness in Chinese adults with high atherosclerotic risk measured by brachial-ankle pulse wave velocity (baPWV).Design, Setting, and ParticipantsThis retrospective cohort study enrolled 5105 adults with high atherosclerotic risk from the Kailuan General Hospital from 2010 to 2020. Data were analyzed from February 2021 to April 2022.ExposuresStatin use information was retrieved from electronic medical records from 2010 to 2020, and statin users were those who have been prescribed any statin medications at least 6 months before baPWV measurements. Statin users were 1:1 matched with nonstatin users by propensity score method.Main Outcomes and MeasuresProgression of baPWV was assessed using the absolute difference between baseline and follow-up baPWV, divided by the follow-up time in years. Multivariable linear regression models were used to estimate the association between statin use and arterial stiffness.ResultsAmong 5105 adults with assessment of baPWV (mean [SD] age: 60.8 [9.7] years; 3842 [75.3%] men and 1263 [24.7%] women), 1310 statin users were matched with 1310 nonstatin users (mean [SD] age, 63.2 [9.3] years). Compared with nonstatin users, statin users were associated with significantly lower baPWV at baseline (difference: −33.6 cm/s; 95% CI, −62.1 to −5.1 cm/s). Among 1502 adults with repeated assessment of baPWV, 410 statin users were matched with 410 nonstatin users (mean [SD] age, 62.9 [9.2] years). Compared with nonstatin users, statin users had significantly slower progression of baPWV (difference, −23.3 cm/s per year; 95% CI, −40.6 to −6.0 cm/s per year) during a mean (SD) follow-up of 4.8 (2.7) years. A significantly slower progression of baPWV was observed in continuous statin users (difference, −24.2 cm/s per year; 95% CI, −42.2 to −6.3 cm/s per year) and high adherent users (difference, −39.7 cm/s per year; 95% CI, −66.9 to −12.4 cm/s per year), but not in discontinued users (difference, −17.3 cm/s per year; 95% CI, −52.4 to 17.8 cm/s per year) and low adherent users (difference, −17.9 cm/s per year; 95% CI, −36.5 to 0.7 cm/s per year), compared with nonstatin users.Conclusions and RelevanceIn this cohort study, statin use was associated with slower progression of arterial stiffness in Chinese adults with high atherosclerotic risk.

Item Type:	Article
Authors/Creators:	Zhou, YF and Wang, Y and Wang, G and Zhou, Z and Chen, S and Geng, T and Zhang, YB and Wang, Y and Chen, JX and Pan, A and Wu, S
Keywords:	statin, arterial stiffness, atherosclerotic cardiovascular disease
Journal or Publication Title:	JAMA Network Open
Publisher:	American Medical Association
ISSN:	2574-3805
DOI / ID Number:	10.1001/jamanetworkopen.2022.18323
Copyright Information:	© 2022 Zhou YF et al. JAMA Network Open. This is an open access article distributed under the terms of the Creative Commons CC-BY License.
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