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Childhood cardiorespiratory fitness and the early markers of kidney disease in middle age: A population-based cohort study

Liu, C, Fraser, BJ ORCID: 0000-0002-1752-5431, He, Y, Jose, MD ORCID: 0000-0002-9589-0071, Magnussen, CG ORCID: 0000-0002-6238-5730, Tian, J ORCID: 0000-0001-7746-7782, Dwyer, T and Venn, AJ ORCID: 0000-0001-7090-1398 2022 , 'Childhood cardiorespiratory fitness and the early markers of kidney disease in middle age: A population-based cohort study' , Journal of Science and Medicine in Sport, vol. 25, no. 6 , pp. 499-504 , doi: 10.1016/j.jsams.2022.03.005.

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Abstract

Objectives:To investigate the relationship of childhood cardiorespiratory fitness with early markers of chronic kidney disease, glomerular hyperfiltration and albuminuria, in midlife.Design:Prospective cohort study.Methods:This study included 1371 participants aged 36-49 years who participated in the 1985 Australian Schools Health and Fitness Survey when they were 7-15 years of age. Childhood cardiorespiratory fitness was estimated by the time taken to complete a 1.6- km run. Blood and urine samples were collected at follow-up. Log-binomial regression was used to determine the associations of childhood cardiorespiratory fitness with glomerular hyperfiltration [estimated glomerular filtration rate (mL/min/1.73 m2) > 95th percentile standardized for age and sex] and albuminuria (urine albumin-to-creatinine ratio ≥ 2.5 mg/mmol in males or ≥3.5 mg/mmol in females) in midlife.Results:Compared with women with high childhood cardiorespiratory fitness, those with lower childhood cardiorespiratory fitness had a higher risk of glomerular hyperfiltration in midlife after adjusting for childhood age, the duration of follow-up, and midlife smoking status [adjusted relative risk = 2.86, 95% confidence interval, 1.04-7.86 for individuals with moderate childhood cardiorespiratory fitness (P = 0.04), and adjusted relative risk = 3.38, 95% confidence interval, 1.13-10.14 for individuals with low childhood cardiorespiratory fitness (P = 0.03)]. Further adjustment for childhood and midlife body mass index resulted in a slightly attenuated and statistically non-significant association. No significant associations were found with glomerular hyperfiltration in males or albuminuria in either males or females.Conclusions:Low cardiorespiratory fitness in childhood may increase the risk of glomerular hyperfiltration in midlife in females, possibly via a path through adult cardiorespiratory fitness.

Item Type: Article
Authors/Creators:Liu, C and Fraser, BJ and He, Y and Jose, MD and Magnussen, CG and Tian, J and Dwyer, T and Venn, AJ
Keywords: cardiorespiratory fitness, glomerular hyperfiltration, albuminuria, kidney disease, child, adult
Journal or Publication Title: Journal of Science and Medicine in Sport
Publisher: Elsevier Australia
ISSN: 1440-2440
DOI / ID Number: 10.1016/j.jsams.2022.03.005
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Copyright 2022 Sports Medicine Australia

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