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Does aspirin have an effect on risk of death in patients with COVID-19? A meta-analysis

Ma, S, Su, W, Sun, C, Lowe, S, Zhou, Z ORCID: 0000-0002-0835-8686, Liu, X, Qu, G, Xia, W, Xie, P, Wu, B, Gao, J, Feng, L and Sun, Y 2022 , 'Does aspirin have an effect on risk of death in patients with COVID-19? A meta-analysis' , European Journal of Clinical Pharmacology , pp. 1-18 , doi: 10.1007/s00228-022-03356-5.

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Abstract

PurposeThe coronavirus disease 2019 (COVID-19) pandemic has shown unprecedented impact world-wide since the eruption in late 2019. Importantly, emerging reports suggest an increased risk of thromboembolism development in patients with COVID-19. Meanwhile, it is found that aspirin reduced mortality in critically ill patients with non-COVID-19 acute respiratory distress syndrome. Therefore, a meta-analysis was performed to investigate the effects of aspirin on COVID-19 mortality.MethodsA systematic literature search was conducted in 10 electronic databases and 4 registries. Random effects models were used to calculate pooled relative risks (RRs) with 95% confidence intervals (Cis) to estimate the effect of aspirin on COVID-19 mortality. Relevant subgroup analyses and sensitivity analyses were also performed.ResultsThe results showed that aspirin use was associated with a reduction in COVID-19 mortality (adjusted RR 0.69; 95% CI 0.500.95; P P P = 0.04), and results from cohort studies suggested that aspirin use was a protective factor for COVID-19 mortality (adjusted RR 0.73; 95% CI 0.520.99; P = 0.04). Meanwhile, aspirin use was not associated with bleeding risk (crude RR 1.22; 95% CI 0.801.87; P = 0.96).ConclusionsThis meta-analysis found that aspirin use was associated with a reduction in mortality in patients with COVID-19 and not with an increased risk of bleeding.

Item Type: Article
Authors/Creators:Ma, S and Su, W and Sun, C and Lowe, S and Zhou, Z and Liu, X and Qu, G and Xia, W and Xie, P and Wu, B and Gao, J and Feng, L and Sun, Y
Keywords: aspirin, COVID-19, mortality, meta-analysis
Journal or Publication Title: European Journal of Clinical Pharmacology
Publisher: Springer-Verlag
ISSN: 0031-6970
DOI / ID Number: 10.1007/s00228-022-03356-5
Copyright Information:

Copyright 2022 The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature

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