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Abstract

A robust, portable and miniature battery powered gradient capillary liquid chromatograph (total weight ~2.7 kg, without battery ~2.0 kg), with integrated microfluidic injection, column heating and high sensitivity low-UV absorbance detection is presented. The portable capillary chromatograph, was applied with a packed reversed-phase capillary column (100 mm x 300 μm I.D., 5 μm ODS), housed within an integrated capillary column heater controlled by a proportional-integral-derivative (PID) chip module. The system delivered retention time and peak area relative standard deviation in isocratic mode of −1 based upon a 316 nL injection volume, with separation efficiencies of between 18,000 and 29,700 N m−1, with sub-4 min run times. The portable capillary LC system was successfully coupled to a small footprint portable mass spectrometer (Microsaic 4500 MiD) to demonstrate compatibility and point-of-need miniaturised LC-MS capability.

Item Type:	Article
Authors/Creators:	Lam, SC and Coates, LJ and Hemida, MH and Gupta, V and Haddad, PR and Macka, M and Paull, B
Keywords:	Miniaturisation, portable, capillary liquid chromatography, ultraviolet light-emitting diode-based detector, column heater, portable mass spectrometer
Journal or Publication Title:	Analytica Chimica Acta: International Journal Devoted to All Branches of Analytical Chemistry
Publisher:	Elsevier Science Bv
ISSN:	0003-2670
DOI / ID Number:	https://doi.org/10.1016/j.aca.2019.12.014
Copyright Information:	© 2019 Elsevier B.V. All rights reserved.
Related URLs:	Google Scholar: Gupta, V UTAS Profile: Gupta, V UTAS Profile: Haddad, PR Google Scholar: Macka, M UTAS Profile: Macka, M Google Scholar: Paull, B UTAS Profile: Paull, B
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