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Miniature and fully portable gradient capillary liquid chromatograph

Lam, SC, Coates, LJ, Hemida, MH, Gupta, V ORCID: 0000-0003-1458-824X, Haddad, PR ORCID: 0000-0001-9579-7363, Macka, M ORCID: 0000-0002-6792-2574 and Paull, B ORCID: 0000-0001-6373-6582 2020 , 'Miniature and fully portable gradient capillary liquid chromatograph' , Analytica Chimica Acta: International Journal Devoted to All Branches of Analytical Chemistry, vol. 1101 , pp. 199-210 , doi: 10.1016/j.aca.2019.12.014.

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Abstract

A robust, portable and miniature battery powered gradient capillary liquid chromatograph (total weight ~2.7 kg, without battery ~2.0 kg), with integrated microfluidic injection, column heating and high sensitivity low-UV absorbance detection is presented. The portable capillary chromatograph, was applied with a packed reversed-phase capillary column (100 mm x 300 μm I.D., 5 μm ODS), housed within an integrated capillary column heater controlled by a proportional-integral-derivative (PID) chip module. The system delivered retention time and peak area relative standard deviation in isocratic mode of −1 based upon a 316 nL injection volume, with separation efficiencies of between 18,000 and 29,700 N m−1, with sub-4 min run times. The portable capillary LC system was successfully coupled to a small footprint portable mass spectrometer (Microsaic 4500 MiD) to demonstrate compatibility and point-of-need miniaturised LC-MS capability.

Item Type: Article
Authors/Creators:Lam, SC and Coates, LJ and Hemida, MH and Gupta, V and Haddad, PR and Macka, M and Paull, B
Keywords: Miniaturisation, portable, capillary liquid chromatography, ultraviolet light-emitting diode-based detector, column heater, portable mass spectrometer
Journal or Publication Title: Analytica Chimica Acta: International Journal Devoted to All Branches of Analytical Chemistry
Publisher: Elsevier Science Bv
ISSN: 0003-2670
DOI / ID Number: 10.1016/j.aca.2019.12.014
Copyright Information:

© 2019 Elsevier B.V. All rights reserved.

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