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Abstract

Introduction:Older people in residential aged care facilities (RACFs) have a high risk of safety issues and concerns about the potential quality of care received. This narrative review investigates the types of actual drug-related harms, their prevalence, reporting of any standard definitions for these harms, and their identification methods.Areas covered:The authors conducted a systematic search on Ovid Embase, Ovid Medline, and PubMed from March 2001 to March 2021. This narrative review included all types of studies targeting aged care residents aged 65 years and above with actual drug-related harms.Expert opinion:The prevalence of actual drug-related harms in residents ranged from 0.07% to 63.0%. Falls, drug-drug interactions, neuropsychiatric symptoms, anaphylaxis, urinary tract infection, hypoglycemia, hypokalaemia, and acute kidney injury are the most common drug-related harms in older residents. Psychotropic drugs are the most common drug class implicated in these harms. Evidence related to the association between individual psychotropic drugs and injury, or harm is also lacking. Due to the variation in study duration, reported prevalence, identification methods, and absence of a definition for actual drug-related harms in most studies, further research is mandated to understand the prevalence and clinical implications of drug-related harms in older residents.

Item Type:	Article
Authors/Creators:	Ali, S and Curtain, C and Bereznicki, LRE and Salahudeen, MS
Keywords:	harms, ADEs, older people, RACFs, drug-related harm, medication-related harm
Journal or Publication Title:	Expert Opinion on Drug Safety
Publisher:	Taylor & Francis
ISSN:	1474-0338
DOI / ID Number:	https://doi.org/10.1080/14740338.2022.2084071
Copyright Information:	Copyright 2022 Informa UK Limited, trading as Taylor & Francis Group
Related URLs:	Google Scholar: Curtain, C UTAS Profile: Curtain, C Google Scholar: Bereznicki, LRE UTAS Profile: Bereznicki, LRE Google Scholar: Salahudeen, MS
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