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Persistence of Adverse drug reaction-related hospitalization risk following discharge

Schmid, O, Bereznicki, B ORCID: 0000-0001-8463-4817, Peterson, GM ORCID: 0000-0002-6764-3882, Stankovich, J ORCID: 0000-0001-9344-7749 and Bereznicki, L ORCID: 0000-0003-3974-3437 2022 , 'Persistence of Adverse drug reaction-related hospitalization risk following discharge' , International journal of environmental research and public health, vol. 4, no. 19 , pp. 1-12 , doi:

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This retrospective cohort study analyzed the administrative hospital records of 91,500 patients with the aim of assessing adverse drug reaction (ADR)-related hospital admission risk after discharge from ADR and non-ADR-related admission. Patients aged ≥18 years with an acute admission to public hospitals in Tasmania, Australia between 2011 and 2015 were followed until May 2017. The index admissions (n = 91,550) were stratified based on whether they were ADR-related (n = 2843, 3.1%) or non-ADR-related (n = 88,707, 96.9%). Survival analysis assessed the post-index ADR-related admission risk using (1) the full dataset, and (2) a matched subset of patients using a propensity score analysis. Logistic regression was used to identify the risk factors for ADR-related admissions within 90 days of post-index discharge. The patients with an ADR-related index admission were almost five times more likely to experience another ADR-related admission within 90 days (p < 0.001). An increased risk persisted for at least 5 years (p < 0.001), which was substantially longer than previously reported. From the matched subset of patients, the risk of ADR-related admission within 90 and 365 days more than doubled in the patients with an ADR-related index admission (p < 0.0001). These admissions were often attributed to the same drug class as the patients' index ADR-related admission. Cancer was a major risk factor for ADR-related re-hospitalization within 90 days; other factors included heart failure and increasing age.

Item Type: Article
Authors/Creators:Schmid, O and Bereznicki, B and Peterson, GM and Stankovich, J and Bereznicki, L
Keywords: adverse drug reactions; medication errors; medication safety; adverse drug event; hospital admission; risk factors
Journal or Publication Title: International journal of environmental research and public health
Publisher: MDPI
ISSN: 1660-4601
DOI / ID Number:
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Copyright 2022 by the authors. Licensee MDPI, Basel, Switzerland.This article is an open access article distributed under the terms andconditions of the Creative Commons Attribution (CC BY) license (

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