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Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimers disease

Zhu, W, Neuhaus, A, Beard, DJ, Sutherland, BA ORCID: 0000-0002-0791-0950 and DeLuca, GC 2022 , 'Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimers disease' , Brain: A Journal of Neurology, vol. 145, no. 7 , pp. 2276-2292 , doi:

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To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and glucose to active neurons. Rather than relying on metabolic feedback signals such as the consumption of oxygen or glucose, the main signalling pathways rely on the release of vasoactive molecules by neurons and astrocytes, which act on contractile cells. Vascular smooth muscle cells and pericytes are the contractile cells associated with arterioles and capillaries, respectively, which relax and induce vasodilation. Much progress has been made in understanding the complex signalling pathways of neurovascular coupling, but issues such as the contributions of capillary pericytes and astrocyte calcium signal remain contentious. Study of neurovascular coupling mechanisms is especially important as cerebral blood flow dysregulation is a prominent feature of Alzheimer's disease. In this article we will discuss developments and controversies in the understanding of neurovascular coupling and finish by discussing current knowledge concerning neurovascular uncoupling in Alzheimer's disease.

Item Type: Article
Authors/Creators:Zhu, W and Neuhaus, A and Beard, DJ and Sutherland, BA and DeLuca, GC
Keywords: disease; functional hyperaemia; neurovascular coupling; neurovascular uncoupling; pericyte
Journal or Publication Title: Brain: A Journal of Neurology
Publisher: Oxford Univ Press
ISSN: 0006-8950
DOI / ID Number:
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Copyright 2022 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse,distribution, and reproduction in any medium, provided the original work is properly cited

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