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Molecular mechanisms of intestinal inflammation leading to colorectal cancer

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Shastri, S, Vemuri, R ORCID: 0000-0002-3238-426X, Guven, N ORCID: 0000-0003-3782-767X, Shastri, MD ORCID: 0000-0002-1012-2779 and Eri, R ORCID: 0000-0003-1688-8043 2017 , 'Molecular mechanisms of intestinal inflammation leading to colorectal cancer' , AIMS Biophysics, vol. 4, no. 1 , pp. 152-177 , doi: 10.3934/biophy.2017.1.152.

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Abstract

Inflammatory bowel disease (IBD) is recognized as a leading cause in the development of colorectal cancer (CRC). Inflammatory bowel disease associated colorectal cancer (IBD-CRC) is a growing healthcare burden, causing significant morbidity and mortality world-wide. In the present review, relevant preclinical models of IBD-CRC, a concise overview of potential molecular mechanisms that are involved and responsible for IBD associated colonic tumorigenesis along with the current and the future therapeutic approaches including the role of novel natural and synthetic compounds for the prevention and treatment of IBD-CRC are outlined. This review will benefit various clinicians and translational researchers working in the area of IBD-CRC to have a quick snap-shot of the ongoing trends in IBD-CRC research and discoveries.

Item Type: Article
Authors/Creators:Shastri, S and Vemuri, R and Guven, N and Shastri, MD and Eri, R
Journal or Publication Title: AIMS Biophysics
Publisher: AIMS Press
ISSN: 2377-9098
DOI / ID Number: 10.3934/biophy.2017.1.152
Copyright Information:

© 2017 Rajaraman Eri, et al., licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0 License (http://creativecommons.org/licenses/by/4.0)

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