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Prevalence implications of the 2017 American Academy of Pediatrics hypertension guideline and associations with adult hypertension

Khoury, M, Khoury, P, Bazzano, L, Burns, TL, Daniels, S, Dwyer, T, Ikonen, J, Jacobs, DR, Juonala, M, Kahonen, M, Prineas, R, Raitakari, OT, Steinberger, J, Venn, A ORCID: 0000-0001-7090-1398, Viikari, J, Woo, JG, Sinaiko, A and Urbina, EM 2022 , 'Prevalence implications of the 2017 American Academy of Pediatrics hypertension guideline and associations with adult hypertension' , Journal of Pediatrics, vol. 241 , 22-28.e4 , doi:

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Objective:To evaluate the impact of the 2017 American Academy of Pediatrics hypertension Clinical Practice Guideline (CPG), compared with the previous guideline ("Fourth Report"), on the frequency of hypertensive blood pressure (BP) measurements in childhood and associations with hypertension in adulthood using data from the International Childhood Cardiovascular Cohort Consortium.Study design:Childhood BPs were categorized in normal, prehypertensive/elevated, and hypertensive (stage 1 and 2) ranges using the Fourth Report and the CPG. Participants were contacted in adulthood to assess self-reported hypertension. The associations between childhood hypertensive range BPs and self-reported adult hypertension were evaluated.Results:Data were available for 34 014 youth (10.4 ± 3.1 years, 50.6% female) with 92 751 BP assessments. Compared with the Fourth Report, the CPG increased hypertensive readings from 7.6% to 13.5% and from 1.3% to 2.5% for stage 1 and 2 hypertensive range, respectively (P P Conclusions:The CPG significantly increased the prevalence of childhood BPs in hypertensive ranges and improved the sensitivity, without an overall strengthened association, of predicting self-reported adult hypertension.

Item Type: Article
Authors/Creators:Khoury, M and Khoury, P and Bazzano, L and Burns, TL and Daniels, S and Dwyer, T and Ikonen, J and Jacobs, DR and Juonala, M and Kahonen, M and Prineas, R and Raitakari, OT and Steinberger, J and Venn, A and Viikari, J and Woo, JG and Sinaiko, A and Urbina, EM
Keywords: pediatric, hypertension, sensitivity, specificity, guideline
Journal or Publication Title: Journal of Pediatrics
Publisher: Elsevier Inc.
ISSN: 0022-3476
DOI / ID Number:
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2021 Elsevier Inc. All rights reserved.

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