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Abstract

Experiments carried out in mice about 30 years ago
indicated that the exposure to ultraviolet radiation
(UVR) could down-regulate cell-mediated immunity.
Since then, considerable progress has been made to
elucidate the complex cascade that starts with the
absorption of photons at or just below the body surface
and ends with the generation of T cells that can
suppress immune responses. More recently it has been
recognized that these cells belong to a subset of T cells
called T-regulatory cells, which are CD41CD251 and
express the transcription factor Foxp3. T-regulatory
cells are involved in the maintenance of peripheral
tolerance and have been proposed to be particularly
important in avoiding autoimmunity.

Item Type:	Article
Authors/Creators:	Norval, M and Malley, RC and Woods, GM
Journal or Publication Title:	Photodermatology, Photoimmunology & Photomedicine
ISSN:	0905-4383
DOI / ID Number:	10.1111/j.1600-0781.2007.00295.x
Additional Information:	The definitive published version is available online at: http://interscience.wiley.com
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