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New approaches for fabrication of microfluidic capillary electrophoresis devices with on-chip conductivity detection
journal contribution
posted on 2023-05-26, 15:22 authored by Rosanne Guijt, Baltussen, E, van der Steen, G, Schasfoort, RBM, Schlautmann, S, Billiet, HAH, Frank, J, van Dedem, GWK, van den Berg, AIn practice, microfluidic systems are based on the principles of capillary electrophoresis (CE), for a large part due to the simplicity of electroosmotic pumping. In this contribution, a universal conductivity detector is presented that allows detection of charged species down to the M level. Additionally, powderblasting is presented as a novel technique for direct etching of microfluidic networks. This method allows creation of features down to 50 ˜í¬¿M with a total processing time (design to device) of less than one day. The performance of powderblasted devices with integrated conductivity detection is illustrated by the separation of lithium, sodium, and potassium ions and that of fumaric, malic, and citric acid.
History
Publication title
ElectrophoresisVolume
22Article number
2Number
2Pagination
235-241ISSN
0173-0835Publication status
- Published
Rights statement
Copyright 2001 Wiley-VCH Verlag GmbH & Co. KGaARepository Status
- Restricted
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